DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-53

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_503771.1	Gene:	ugt-53 / 178744	WormBaseID:	WBGene00020182	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	131/533 - (24%)
Similarity:	228/533 - (42%)	Gaps:	66/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHLIV 71
            :||.:|  :..:...|||..::...|||:....:....|:..||||.||..:..::.:.|:.
Worm     5 IFLTVL--INFSSCLNILFYYAVIGPSHIAYLRNTIGKLLARGHNVDVVFAVYNELANLDLF--- 64

  Fly    72 VPMKEEQERIMEDQMTEMAGQKNSL--VSTMYRLLTSMDVMINAQAELLSDP--RFQRIYETKFD 132
                .:..||..::..:....|.:.  .|.|:              |....|  .|:..:|:.:.
Worm    65 ----PDVRRIYYNRHADPDYWKKNANHFSNMF--------------EKSPTPLGEFEIFHESGYQ 111

  Fly   133 LMILGYFIND-----------FQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSELSYVPLMG-- 184
            |..:.  |||           :.:|.:........|...:|.:|:|......|..|.::...|
Worm   112 LCKIA--INDLKLIEFLKSGKYDIGFSSDYDPCGNILMTAAGIPSIGSLIATPIFLPHIVSAGLP 174

  Fly   185 TVAT-QPMGFLKRTENALKSLLFEFI-FVVFDYKLT----RIYNDVFPEQ---DMPTLKELRKNI 240
            |||: .........:::|...:|..| ...:.|.::    |.||::..::   :.|.:..:.:.|
Worm   175 TVASVYGTSLYPEHDSSLYDKIFNLIRLTYYHYAISPDMDRKYNNLITKRFGNNFPDVGTIERGI 239

  Fly   241 SMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSS- 304
            .:.||.||...|.. ||:.|.:..|||:.:: |...||.:.::.:|..|...|..|.|:.|.::
Worm   240 DIIFVNSHDFLEQQ-RPMSPKIKYIGGMAIR-KAKQLPDEFEKILSVPKSAYVLFSFGTQVPTAK 302

  Fly   305 ---TVRPEIVQIIFKVLSELKENVIWKWEDLE---NTPGNSSNILYKNWLPQDDILAHPNTKLFI 363
               .:|...|. .||....:  ..:||::.||   :......||....||||.::|.....||||
Worm   303 MPLPIRRNFVG-AFKKFPNV--TFLWKYDSLELDADIFQGVENIHRLEWLPQTELLHDNRVKLFI 364

  Fly   364 THAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQK 428
            :|.|.....|....|||::::|:|.||..||......|.||.||...:|..::..||.|:|||.|
Worm   365 SHMGLNSYLETATAGVPVLSIPLFADQQNNAQNTRDRGMGLLLDRDKLTTKNIESALHELLENPK 429

  Fly   429 YKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPN-LQSPSVHMNFIQLNNLDIYALIVTIL 492
            |.......|.:..::|..|..:.:.|.|:..|:.|... |:.|...::.......||  |::...
Worm   430 YLSNARSISKMILEKPDKANDTFIHWLEFTARNPGLGRVLKLPGAELSPFYYYCGDI--LLLVFC 492

  Fly   493 VLFVLLTRLVAKI 505
            :||::|..::..|
Worm   493 ILFIILHTVLRTI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	122/493 (25%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	124/507 (24%)
ugt-53	NP_503771.1	UDPGT	29..497	CDD:330975	122/497 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14449
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810