DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-62

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_497918.1	Gene:	ugt-62 / 175591	WormBaseID:	WBGene00010904	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	139/542 - (25%)
Similarity:	260/542 - (47%)	Gaps:	44/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLK----------PK 61
            :||||||.|::.:.|..:...::   |.:.....||:.|...||:||::.:..          ||
Worm     6 LFLLLLGAVSAYKYAVFVPYMAN---SQVQFCTRVAEVLANGGHDVTMIHLSHLPDYKTDVKIPK 67

  Fly    62 VTHKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSL--VSTMYRLLTSMDVMI-NAQAELLSDPRF 123
              :..:|.:...::...:.::|.:.:....:...|  :..|..:.:....|. :....::.:..|
Worm    68 --NIKVHRVEAYVEGLTKALLEKEQSAFIFKDTGLKDMPAMMSMFSRFGKMFQDGCRNIVRNKEF 130

  Fly   124 QRIYET-KFDLMILGYFINDFQLGVAHKLKVPVIINWMS--APVPAIDKYTGNPSELSYVPLMGT 185
            .:..|. ||| :...|..:...:|:.|..|:|..: |::  |.:..:.:..|.|...||||.:..
Worm   131 MKWLENEKFD-VAYSYIYSSCPIGLIHAAKIPSWV-WLNSGALMDFVAETVGVPIIPSYVPPLMM 193

  Fly   186 VATQPMGFLKRTENALKSLLFEFIFVVFDYKL-----TRIYNDVFPEQDMPTLKELRKNISMAFV 245
            .:...|||..|    :||.:...:..|...::     |:|:.|...:.:.|...:|.....:..|
Worm   194 ESDDEMGFFFR----MKSFIGHTLMTVLHRRMTSNGETQIFRDELNDPNFPHTMDLGAKCPLVIV 254

  Fly   246 GSHLISEGPIRPLVPALIEIGGIQVK-DKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTVRPE 309
            .|:.:.:.| ||.:..::.|||:.|. |...||..:..: ||...:|.:..|.||...:..:..|
Worm   255 NSNELYDLP-RPTLAKVVNIGGLGVGFDSAKPLTGEFKK-ISETGKGMIVFSFGSVAAAHDMPLE 317

  Fly   310 IVQIIFKVLSELKE-NVIWKW--EDL-ENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGG 370
            ....|.:..|.|.: ..:.::  :|| :..|.|..  |:| ||||.|:|.|..||.||||.|...
Worm   318 WKNSILEAFSSLPDYQFLMRYVADDLNDRLPKNVH--LFK-WLPQKDLLLHNKTKAFITHGGYNS 379

  Fly   371 ITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQ 435
            :.||...|||:|.:.:|||||.|:.:.:|.|:.:.:....|::.::..|:.|::||..|||.:.:
Worm   380 MQEAISAGVPLVTIALFGDQPKNSKVAKKHGFAVNIQKGEISKKTIVKAIMEIVENDSYKQKVSR 444

  Fly   436 FSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYA-LIVTILVLFVLLT 499
            .|.:.|.:||...:.::.|:|::...:...||:.....:||.|.::||:.. |.:.|.::|.:..
Worm   445 LSAMVRAQPMKPAERLLKWSEFLAEFKTLDNLEPAGQKLNFFQYHSLDVITFLFIVIFIVFYIGY 509

  Fly   500 RLVAKIVWNKFGGKAKISQTKK 521
            |.:..::...|..|.: ::|||
Worm   510 RFMRAVIRCCFCKKCE-TKTKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	123/485 (25%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	128/508 (25%)
ugt-62	NP_497918.1	UDPGT	37..520	CDD:278624	125/495 (25%)
ugt-62	NP_497918.1	egt	<251..471	CDD:223071	70/224 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14329
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810