DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt-28

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_491437.1	Gene:	ugt-28 / 172086	WormBaseID:	WBGene00015693	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	142/550 - (25%)
Similarity:	248/550 - (45%)	Gaps:	51/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVT-VVSMLKP---------KV 62
            ||:......||...|||....:.:.||......:|..|.:.||||| ::.::.|         |:
Worm     5 FLIFSSFFCSTSSLNILVYSPAFAASHSNFLGKLADTLTERGHNVTYLMPVVDPEKRDECIGVKL 69

  Fly    63 THKDIHLIVVPMKEE----------QERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMINAQAEL 117
            | ||  |::|...||          ...|||..........||  ..|:....| |:.:..:...
Worm    70 T-KD--LVIVEPDEEMMSFKKGSTPNGEIMELFWKSEMDSSNS--RDMFSFFNS-DMKLACRNFH 128

  Fly   118 LSDPRFQRIYETKFDLMILGYFINDFQLGVAHKLKV-PVIINWMSAPVPAIDKYTGNPSELSYVP 181
            .....|:::....||:.||.. :....||....|.: ..|:...|....|:..|.|.|.:.||||
Worm   129 KRRDIFEQMKSRNFDVAILEP-VTICGLGFVKALGIEKTILASSSTFYDAVMDYIGEPLDYSYVP 192

  Fly   182 LMGTVATQPMGFLKRTEN--ALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISMAF 244
            ...:|....|...:|.||  .:|.:... :..:||.:: :.|.: |..:|:|..:||..:.|:.|
Worm   193 SGFSVTGDVMTMAERYENWMVVKEINIA-LHDMFDGEM-KSYRE-FLGEDLPNWRELLSSASIFF 254

  Fly   245 VGSHLISEGPIRPLVPALIEIGGIQVK---DKPDPLPKDIDQFISNAKQGAVFLSLGSNVKSSTV 306
            |.::...:.| |.::...:.||||.:.   .|...|.||.:..:.. :...|.:|.||.|||:.:
Worm   255 VNANPFLDFP-RAVLQKTVPIGGISINLKWIKEQKLTKDWEDILEK-RTKTVLISFGSMVKSAYM 317

  Fly   307 RPEIVQI-IFKVLSELKE-NVIWKWE-DLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGK 368
             |:|.:. :.:|:..:.: ..|:|:| |..:.....|||.:..|:||..:|..|....|:||.|.
Worm   318 -PKIWRNGLLEVIKSMPDVTFIFKYESDEVSFADGISNIHFSKWVPQTALLNDPRLSAFVTHGGL 381

  Fly   369 GGITEAQYHGVPMVALPIFGDQPGNAALMEKSG-----YGLALDLLSITEDSLRDALKEVLENQK 428
            |...|..|.|.|.|.:|:|.||..||.::.:..     :..:::.:.:|    |.||.:||.::.
Worm   382 GSTMELAYSGKPGVVIPVFADQIRNARMIARHNGVIYLHKNSMENVKVT----RKALTDVLYDES 442

  Fly   429 YKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILV 493
            ||:...:.:.:..::|.:..::|:.:||::..|...||......|:|:.|....|||||.....:
Worm   443 YKKNAEKLTDILMNQPYSPMENVIKYTEFVGEHGPFPNTDPYGRHLNYFQKTFFDIYALFALFYI 507

  Fly   494 LFVLLTRLVAKIVWNKFGGKAKISQTKKKQ 523
            ....:..:..:.::.|......:.::||.:
Worm   508 SVGTIIAISIRFIYQKARKYFTLEKSKKTE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	130/492 (26%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	133/515 (26%)
ugt-28	NP_491437.1	UDPGT	40..536	CDD:278624	131/512 (26%)
ugt-28	NP_491437.1	egt	<193..472	CDD:223071	77/288 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810