DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	155/548 - (28%)
Similarity:	274/548 - (50%)	Gaps:	63/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVFLLLLGVVASTQGANILG---LFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDI 67
            |:||:|.|        ::||   |......||.:....:.:.|.:.||::.|   |.|     ::
  Rat    14 FLFLVLWG--------SVLGDKLLVVPQDGSHWLSMKEIVEHLSERGHDIVV---LVP-----EV 62

  Fly    68 HLIVVPMKEEQERI------MEDQMTEMAGQKNS-------LVSTMYRLLTSMDVM----INAQA 115
            :|::...|..:.:.      :|:..|......|:       |::.:.....:|.|:    .:.|:
  Rat    63 NLLLGESKYYRRKSFPVPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDMCFFSCQS 127

  Fly   116 ELLSDPRFQRIYETKFD------LMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNP 174
            .|........:.|.:||      .|..|..:.::       ||:|.:..:...|.........:|
  Rat   128 LLKDSATLSFLRENQFDALFTDPAMPCGVILAEY-------LKLPSVYLFRGFPCSLEHMLGQSP 185

  Fly   175 SELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPTLKELRKN 239
            |.:||||...|..:..|.|.:|..|.:.::|..:::.....|...:.:|:. ::|: :|..|.:|
  Rat   186 SPVSYVPRFYTKFSDHMTFPQRLANFIANILENYLYHCLYSKYEILASDLL-KRDV-SLPALHQN 248

  Fly   240 ISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKS 303
             |:..:....:.|.| ||::|.:|.|||...|.|.: |.::.:.:: ::.:.|.|..||||.|
  Rat   249 -SLWLLRYDFVFEYP-RPVMPNMIFIGGTNCKKKGN-LSQEFEAYVNASGEHGIVVFSLGSMV-- 308

  Fly   304 STVRPEIVQIIFKVLSELKENVIWKWEDLENTPGN-SSNILYKNWLPQDDILAHPNTKLFITHAG 367
            |.:..:....|.:.|..:.:.|:|::..  ..|.| :.|.:...||||:|:|.||..:.||||:|
  Rat   309 SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSG 371

  Fly   368 KGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQA 432
            ..||.|...:|||||.:|:||||..||..||..|.|:.|::|.:|.|.|.:|||.|:.|:.||:.
  Rat   372 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 436

  Fly   433 IGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVH-MNFIQLNNLDIYALIVTILVLFV 496
            |.:.|:|::|||:......|||.||::||:|||:|: |:.| :.:.|.::||:...::.|::..|
  Rat   437 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVV 500

  Fly   497 LLTRLVAKIVWNK-FGGKAKISQTKKKQ 523
            .:..........| ||||.::.::.|.:
  Rat   501 FIVYKSCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	141/488 (29%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	146/508 (29%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	149/522 (29%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	147/519 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810