DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	534	Identity:	136/534 - (25%)
Similarity:	253/534 - (47%)	Gaps:	87/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSM--------LKPKVTHKD 66
            |||..|...:..|:| :|.. ..||.:....:.:||...|||:||:.|        ..|..|..:
Zfish    16 LLLVTVPVVESGNVL-VFPV-DVSHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFSPHYTSVN 78

  Fly    67 IHLIVVPMKEEQERIMEDQMTEMAGQKNSLV---STMYRLLTSMDV------MINAQAELLSD-- 120
            :        :....:.||.:.....:..:::   ||..||...:::      ||..:.|::::
Zfish    79 L--------KSSGGLSEDFIGPFVSRLMNILREGSTWGRLKLEIEMWQTSLKMIEIEREMITNMI 135

  Fly   121 ---PRFQRIYETKFDLMILG-YFINDFQLGVAHKLKVPVIIN--WMSAPVPAIDKYTGNPSELSY 179
               ...|.:.:.||||::.. .......||  |.||:|::.|  |   .:.....:...||.|||
Zfish   136 EDQQLMQSLKKAKFDLILTDPAMYGGVMLG--HYLKLPIVYNVRW---TIFGEGHFAIAPSPLSY 195

  Fly   180 VPLMGTVATQPMGFLKRTENALKSLLFE--FIFVVFDYKLTRIYNDVFPEQDMPTLKELRKNISM 242
            ||:........|.||:|.:|.:..::.|  ..|::                 .||...|.:.
Zfish   196 VPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLI-----------------APTYNALCER--- 240

  Fly   243 AFVG-----SHLISEGPI------------RPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAK 289
             |:|     .:|:.|..:            ||.:|.::.:.|.|.|.. .|||:|::.|: |:..
Zfish   241 -FIGPEVNFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPS-KPLPQDLEDFVQSSGD 303

  Fly   290 QGAVFLSLGSNVKSSTVRPEIVQIIFKVLSELKENVIWKWEDLE-NTPGNSSNILYKNWLPQDDI 353
            .|.:.:|||:.:  ..:..::.:.|.:..:||.:.:||:::... :..||  |.|..:|:||:|:
Zfish   304 HGVIVMSLGTLI--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGN--NTLVMDWMPQNDL 364

  Fly   354 LAHPNTKLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRD 418
            |.||.|:.|:.|.|..|:.||.|||||::...:..|||.|.:.|...|....:|..::.::|...
Zfish   365 LGHPKTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLK 429

  Fly   419 ALKEVLENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLD 483
            .:||||.:..|::.:.:.|.|::|.|:....:.:||.|:::||:||.:|::.|..|.:...:::|
Zfish   430 TVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVD 494

  Fly   484 IYALIVTILVLFVL 497
            :..::::.:.|.:|
Zfish   495 VILVLISAVSLIIL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	130/502 (26%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	129/511 (25%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	132/523 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740