DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37C2 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	525	Identity:	153/525 - (29%)
Similarity:	258/525 - (49%)	Gaps:	49/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVV-----SMLKPKVT---- 63
            ||.||.|.::.|..|||..::  ..||.|....|...|:..||||||:     ..:|.|.:
Zfish     7 FLSLLTVFSAGQCGNILVWYT--EGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKESDRFS 69

  Fly    64 --HKDIHLIVVPMKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTS--MDVMINAQAELLSDPR-F 123
              |..:......|::..:.:|...:.||.......:...:..|.|  .|:.::....:|..|. .
Zfish    70 YQHFSVSKSAQDMQDFFDELMRFSVFEMDNSSFLEIQMKFFNLGSQHQDMSLSYCDGILKSPELM 134

  Fly   124 QRIYETKFDLMILG--YFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGN-PSELSYVPLMGT 185
            .::.:.|||:::..  |..:|.   ||.:|.||::..:..:...|.::..|. |:..||||...:
Zfish   135 DKLKKGKFDVVLSDPMYPCSDI---VAEELNVPLVYTFRFSVAHAAERMCGQIPAPPSYVPGAMS 196

  Fly   186 VATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRI--------YNDVFPEQDMPTLKELRKNISM 242
            ..|..|.|.:|        :|..:|.:....|:|:        |.:.|...  .:..|:.....:
Zfish   197 KLTDKMSFTER--------IFNMLFYLSQDTLSRLIWRRFDNYYTEYFGRS--TSYCEMMGKADI 251

  Fly   243 AFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLGSNVKSSTV 306
            ..:.::...|.| ||.||....|||:.. ....|||||:::|: |:...|.|..:|||.:  ..|
Zfish   252 WLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSGDDGIVVFTLGSMI--DKV 312

  Fly   307 RPEIVQIIFKVLSELKENVIWKW-EDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGG 370
            ..|:...|...|:::.:.|:|:: .:..:|.|.::.| || |:||:|:|.||.|:.||||.|..|
Zfish   313 PKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRI-YK-WIPQNDLLGHPKTRAFITHGGTNG 375

  Fly   371 ITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALD-LLSITEDSLRDALKEVLENQKYKQAIG 434
            :.||.|||||||.:|:|||||.|...|......:.:| :.|:....|.|.|..|:.:..||:...
Zfish   376 VYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKLNTVINDPSYKENAM 440

  Fly   435 QFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTILVLFVLLT 499
            :.|.::.||||......|||.|:::|::||.:|:..:.::.:.|.:.||::|.:.|:|.|.:.:.
Zfish   441 RLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTTVLTLVLYIC 505

  Fly   500 RLVAK 504
            ..:||
Zfish   506 FKMAK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	143/486 (29%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	144/500 (29%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	147/512 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810