DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37C2 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	533	Identity:	159/533 - (29%)
Similarity:	253/533 - (47%)	Gaps:	65/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVV---SMLKPKVTHKD--- 66
            ||.||.|.::.|..|||...:  ..||.|....|...|:..||||||:   ..|..|....|
Zfish     7 FLSLLTVFSAGQCGNILVWHT--EGSHWINLKIVLDTLLDRGHNVTVLMPDGALFMKAKESDRFS 69

  Fly    67 --------------------IHLIVVPMKEEQERIMEDQMTEM-AGQKNSLVSTMY--RLLTSMD 108
                                :|..|..|  ||..:::.||... .|.::..:...|  .:|.|.:
Zfish    70 YQNFSVSTSAQDMQDFLDELLHFSVFEM--EQLNLLQIQMKFFDLGSRHQDMGLSYCDGILKSPE 132

  Fly   109 VMINAQAELLSDPRFQRIYETKFDLMILG--YFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYT 171
            :|             .::...|||:::..  |..:|.   ||..|.||::.....:....:::..
Zfish   133 LM-------------DKLKTGKFDVLLSDPMYPCSDI---VAEVLNVPLVFTLRFSIAHTMERIC 181

  Fly   172 GN-PSELSYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVFPEQDMPT-LK 234
            |. |:..||||...:..|..|.|.:|..|.|..|..:...::...|....|.:.|   ..|| ..
Zfish   182 GQIPAPPSYVPGAMSKLTDKMSFTERIFNTLFYLSMDTFSIIAWKKFDNYYTEYF---GRPTSYC 243

  Fly   235 ELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFI-SNAKQGAVFLSLG 298
            |:.....:..:.::...|.| ||.||....|||:.. ....|||||:::|: |:...|.|..:||
Zfish   244 EMMGRADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSGDDGIVVFTLG 306

  Fly   299 SNVKSSTVRPEIVQIIFKVLSELKENVIWKW-EDLENTPGNSSNILYKNWLPQDDILAHPNTKLF 362
            |.:  ..|..|:...|...|:::.:.|:|:: .:..:|.|.::.| || |:||:|:|.||.|:.|
Zfish   307 SMI--DKVPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRI-YK-WMPQNDLLGHPKTRAF 367

  Fly   363 ITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALD-LLSITEDSLRDALKEVLEN 426
            |||.|..||.||.|||||||.:|:|||||.|...|...|..:.:| :.|:....|.|.|..|:.:
Zfish   368 ITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKLNTVIND 432

  Fly   427 QKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIVTI 491
            ..||:...:.|.::.||||......|||.|:::|::||.:|:..:.::.:.|.:.||::|.:.|:
Zfish   433 PSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTTV 497

  Fly   492 LVLFVLLTRLVAK 504
            |.|.:.:...:||
Zfish   498 LTLVLYICFKMAK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	149/494 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	150/508 (30%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	153/520 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740