DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	156/535 - (29%)
Similarity:	252/535 - (47%)	Gaps:	109/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHVIVHMAVMKALADRGHNITVVTQ-----MKPK-------------LATH--EN-ITVIIAPPT 80
            ||.:....:::.|..:||.:||:..     :.||             .::|  || .|..:...|
  Rat    34 SHWMNIKIILEELVQKGHEVTVLRPSASVFLDPKETSDLKFVTFPTSFSSHDLENFFTRFVNVWT 98

  Fly    81 EERQR-----YIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIYENPKIKFD 140
            .|..|     |.. |:.:..:|...:..|:.|..|  ||:     :|||     ::.|:   |||
  Rat    99 YELPRDTCLSYFL-YLQDTIDEYSDYCLTVCKEAV--SNK-----QFMT-----KLQES---KFD 147

  Fly   141 LVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGNV-NDPSYVPTVNVALNAGQKTMDF 204
            :||...:....:| ||..|:.|.:.|....|...::..:|.| ..|||||.:...| |||  |.|
  Rat   148 VVFSDAIGPCGEL-IAELLQIPFLYSLRFSPGYTIEKYIGGVLFPPSYVPMIFSGL-AGQ--MTF 208

  Fly   205 GLRFVNFFKYAIMCV------FETVLDYKMNQFYERAFAN--------------------ELEFP 243
            ..|..|     ::|:      |:|..:.|.:.||.:....                    :||||
  Rat   209 IERVHN-----MICMLYFDFWFQTFREKKWDPFYSKTLGRPTTLAEIMGKAEMWLIRSYWDLEFP 268

  Fly   244 NYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-GAIFF 307
            :                     ||.|.|..   |||:..| .|.||||::..|:..:.| |.:.|
  Rat   269 H---------------------PISPNVDY---IGGLHCK-PAKPLPKDIEDFVQSSGEHGVVVF 308

  Fly   308 SLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTK 372
            |||:.|...|  .:..:|:...|:::||:|:|:: |.|..|....|.....||||:|:|.||.||
  Rat   309 SLGSMVRNMT--EEKANIIAWALAQIPQKVLWRF-DGKKPPTLGPNTRLYKWLPQNDLLGHPKTK 370

  Fly   373 LFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLG 437
            .|:||.|..|:.||.:||:||:.:|:||:|..|...|...|....::..||::.::...:.||:.
  Rat   371 AFVTHGGANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVIN 435

  Fly   438 NPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVL- 501
            ||.|::.....||::.|:|.......::|.|:|:||:||.||:|...:..:...::|||.|.:|
  Rat   436 NPFYKKNAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLT 500

  Fly   502 LVSLLLIVTIK-FLF 515
            .|::.:::.:| |||
  Rat   501 CVAVTVVLALKCFLF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	141/491 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	132/464 (28%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	156/535 (29%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	81/225 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740