Protein Alignment Ugt37E1 and UGT2A3

DIOPT Version :9

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 143/528 - (27%)
• Similarity: 235/528 - (44%)
• Gaps: 94/528 - (17%)

  Fly    37 SHVIVHMAVMKALADRGHNITVVTQMKPKLATHE-----NITVIIAPP--TEERQRYIKEYMAEV 94
            ||.:....:::.|..|||.:||:|..||.|..:.     ...|:..|.  |||.:.::...:
Human    34 SHWLNVKVILEELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVHMPQDRTEENEIFVDLAL--- 95

  Fly    95 SNEKP--SFWETMVKA---IVQSSNQLEGQYEFMTHPN--VKEIYENPKIKFDLVFLGLMANTYQ 152
             |..|  |.|::::|.   .|:....|:...|...:..  :|::.|.   .:|::.:..:.....
Human    96 -NVLPGLSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQTLMKKLQET---NYDVMLIDPVIPCGD 156

  Fly   153 LGIAAKLKCPVIISW---VGIPLPFMDTIVGNVNDP-SYVPTVNVALNAGQKTMDFGLRFVNFFK 213
            | :|..|..|.:::.   ||   ..|:...|.:..| ||||   |.:......|.|..|..|...
Human   157 L-MAELLAVPFVLTLRISVG---GNMERSCGKLPAPLSYVP---VPMTGLTDRMTFLERVKNSML 214

  Fly   214 YAIMCVFETVLDYKM-NQFYERAFAN--------------------ELEFPNYHEMKRRVSLLFY 257
            ..:...:....||.. .:||.:|...                    :.|||
Human   215 SVLFHFWIQDYDYHFWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFP-------------- 265

  Fly   258 NYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPK------ELAKFLDKA-DEGAIFFSLGTNVNT 315
                      :|..|....:||:..| .|..|||      |:..|:..: ::|.:.||||:....
Human   266 ----------QPYQPNFEFVGGLHCK-PAKALPKINFYLQEMENFVQSSGEDGIVVFSLGSLFQN 319

  Fly   316 NTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFGNWLPQDDILAHPNTKLFITHAG 379
            .|  .:..:|:...|:::||:|:|:::.  .||.. .:|....:|:||:|:|.||.||.||||.|
Human   320 VT--EEKANIIASALAQIPQKVLWRYKG--KKPSTLGANTRLYDWIPQNDLLGHPKTKAFITHGG 380

  Fly   380 KGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRET 444
            ..|:.||.|||||||.:||||||..|...|...|....::..|||..:|.:.:|.|:.:.:|:|.
Human   381 MNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKEN 445

  Fly   445 IGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIV 509
            ..:.|.::.|:|:......::|.|:|:||:||.||:|......:....::||.|.:    |..:.
Human   446 AMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFL----LACVA 506

  Fly   510 TIKFLFRK 517
            |..|||.|
Human   507 TAIFLFTK 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	129/484 (27%)
		YjiC	27..448	CDD:224732	121/457 (26%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	143/528 (27%)
		egt	<267..498	CDD:223071	81/235 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740