DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	550	Identity:	155/550 - (28%)
Similarity:	256/550 - (46%)	Gaps:	77/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENI 72
            |.|:..||...........:|.:.|.:|..|.:  .|:::||.||.|::||       |.:..:.
Zfish     4 GALLVCLLLCGVDVGWSGRVLVMPGEYSHWHNM--RAIIEALVDRNHSVTV-------LVSSSSP 59

  Fly    73 TVIIAPPTEERQRYIKEYMAEVSNEKPS---FWETMVKA-IVQSSNQLE---------GQYEFMT 124
            ||    |..::.|: ..::.:|:.:|..   .|...... :.::.::||         ..:..:.
Zfish    60 TV----PHTQKARF-DYHVFKVNMDKEEAKVIWSDFTHLWMKETDSKLERGFLIWRVMSNFRRLA 119

  Fly   125 HPNVKEIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPF---MDTIV 179
            ....:.:.:|..:       .:|::|...|.....| :|..|..|.:||   :.|.|   .:.:.
Zfish   120 ADVCRSLLQNDDLLQMLGESHYDVLFSDPMMPCSDL-MAQTLNIPQVIS---LRLTFAYTFERMC 180

  Fly   180 GNV-NDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFP 243
            |.: ..|||||.|.:..:...: |.|..|..|...|.|   ..||  :::|....   .:.|
Zfish   181 GQMPAPPSYVPAVALTDHLTDR-MSFMERVENMLLYFI---HTTV--FRLNTMLT---VDRL--- 233

  Fly   244 NYHEMKRRVSLLFYNYHSAS----------EGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLD 298
             |.|::.:.:.:......|.          |.| ||..|....:||:..| .|.||.||:.:|:.
Zfish   234 -YTEIRGKPTTMCETMGKADIWLIRTYWDFEYP-RPFPPNFKFVGGLHCK-PAKPLSKEMEEFVQ 295

  Fly   299 KA-DEGAIFFSLGTNV-NTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLP 361
            .: |.|.:.||||:.: |..:.|.:|:   ...|.::||:|:|::.. |.....|.|....:|:|
Zfish   296 SSGDHGVVVFSLGSMIKNLTSERANTI---AAALGQIPQKVVWRYSG-KTPETLAPNTKIYDWIP 356

  Fly   362 QDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEH 426
            |:|:|.||.||.||||.|..|:.||.|||||||.||:|.||..|...|...|....|||.|:...
Zfish   357 QNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESK 421

  Fly   427 ELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVAR 491
            :|...::.||.||:|:|:|.:.|.::.|:|:......:||.|:|:|::||.||:.......:...
Zfish   422 DLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQY 486

  Fly   492 NNLDVYGVVL----LVSLLLIVTIKFLFRK 517
            :.|||...:|    |::.|.:....||||:
Zfish   487 HCLDVAAFLLSIAALITFLWVKACCFLFRR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	141/502 (28%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	129/456 (28%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	151/532 (28%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	87/236 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910