DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	567	Identity:	156/567 - (27%)
Similarity:	248/567 - (43%)	Gaps:	79/567 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENI 72
            |.|:..||...........:|.:.|.:|..|.:  ..|::||.|:.|::||:.........|..
Zfish     4 GALLVCLLLCGVDVGWSGRVLVMPGEYSHWHNM--RPVIEALVDKNHSVTVLVGSSSPTVPHTQ- 65

  Fly    73 TVIIAPPTEERQRYIKEYMAEVSNEKPS-------------------------FWETMVKAIVQS 112
                    :||..|   ::.:|:.||..                         .|:.|.|.:...
Zfish    66 --------KERFEY---HVFKVNMEKEEADAAMRDMIHLFTNDTAAKYEGEFVMWKVMSKFVEFG 119

  Fly   113 SNQLEGQYEF-----MTHPNVKEIYENPKIKF-DLVFLGLMANTYQLGIAAKLKCPVIISWVGIP 171
            .....|.::.     :...|...::.:|.:.| ||             :|.||..|.:||.....
Zfish   120 DVYFRGLFDVGLLKTLRDSNYDVLFSDPMMPFSDL-------------MAQKLNIPQVISMRATF 171

  Fly   172 LPFMDTIVGNV-NDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCV-FETVLDYKMNQFYER 234
            ....:.:.|.: ..|||||.|.:..:...: |.|..|..|...|.:..: |..|..:..:.:|..
Zfish   172 AYAAERLCGQMPAPPSYVPAVALTDHLTDR-MSFMERVENMLLYIVHSIAFPLVATFTFDGYYSE 235

  Fly   235 AFANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDK 299
            .....   ....|...:|.:.....:...|.| ||..|....:||:..| .|.||.|||.:|:..
Zfish   236 ILGKP---TTMCETMGKVDICLIRTYWDFEYP-RPFPPNFKFVGGLHCK-PAKPLSKELEEFVQS 295

  Fly   300 A-DEGAIFFSLGTNV-NTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQ 362
            : |.|.:.||||:.: |..:.|.:|:   ...|.::||:|:|::.. |.....|.|....:|:||
Zfish   296 SGDHGVVVFSLGSMIKNLTSERANTI---AAALGQIPQKVVWRYSG-KTPETLAPNTKIYDWIPQ 356

  Fly   363 DDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHE 427
            :|:|.||.||.||||.|..|:.||.|||||||.||:||||..|...:...|....|||.||...:
Zfish   357 NDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHTMGSKD 421

  Fly   428 LEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARN 492
            |...::.|:.||:|:|:|.:.|.::.|:|:......:||.|:|:|::||.||:.......:...:
Zfish   422 LVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYH 486

  Fly   493 NLDVYGVVL----LVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            .|||...:|    |::.|.:....||||:.:...   ..:||...||
Zfish   487 CLDVAAFLLSITALITFLWVKACCFLFRRCVRKT---RPERKRQKNK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	138/501 (28%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	126/455 (28%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	148/534 (28%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	89/241 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740