DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	552	Identity:	157/552 - (28%)
Similarity:	260/552 - (47%)	Gaps:	91/552 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 STMTQSSGGANILGVFGT--------HSP---SHVIVHMAVMKALADRGHNITVVTQ-----MKP 64
            :.|...|....::.:||:        .:|   ||.:....::|||..:||.:.|:..     :|.
Zfish    27 NNMVSVSLWTTVITIFGSLCDGGKILVAPLEGSHWVNMDILIKALHGQGHTVDVIRNANSWFIKE 91

  Fly    65 KLATHENITVIIAPPT----EERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTH 125
            ....::.||:   |.|    ||........|.:...||.| |.::|:..:...:.::..:|.:..
Zfish    92 NSTYYDTITI---PNTKGWDEEFAADFVYKMIKYEKEKGS-WLSIVRLYLNVFDAVKKTHEMVCQ 152

  Fly   126 --PNVKEIYENPKI----KFDLVFLGLMANTYQLGI--AAKLKCPVI--ISWVG--------IPL 172
              .|:.:..|..|:    ::||:   |....:..||  |.|||.|::  :.|..        .|.
Zfish   153 LITNILDSEEILKMLNEKQYDLM---LTDPVWGTGIILAHKLKLPMVYNVRWTTTGEGHFDIAPS 214

  Fly   173 PFMDTIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQF------ 231
            |.           ||:|   :..:.....|.|..|..|:|.|.:       ||.:::.|
Zfish   215 PM-----------SYIP---ITGSGNTDRMSFFQRLKNYFFYLL-------LDLQLSHFNVKQYQ 258

  Fly   232 --YERAFANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELA 294
              .::.|.:.:   |:||:.:...|.........|.| |||:|..|.|||.|. ..|.|||.:|.
Zfish   259 AICDKYFTSRV---NFHELLQGADLWLMRVDFVFEFP-RPTMPNIIYIGGFQC-PPAKPLPHDLE 318

  Fly   295 KFLDKA-DEGAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGNAS-NIFF 356
            .|:..: |.|.|..|||:.:..   .|:.|.. :....::|||:|||::..  .||...| |...
Zfish   319 DFMQSSGDHGVIVMSLGSLIGN---LPENVTAEIAAAFARLPQKVIWRYTG--KKPSTLSNNTLM 378

  Fly   357 GNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDIL 421
            .:|:||.|:|.||.||:||:|.|..||.||.|||||::.:|.|.||..|...:...|..:.|.|.
Zfish   379 VDWMPQKDLLGHPKTKVFISHGGTNGVLEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKLLSIA 443

  Fly   422 TMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHT 486
            .:.|:.|...|:||:..|:||..:.|.|.|::|:|:....|.|:|.|:|:||:||.||::.....
Zfish   444 DLGENTLHAAIQEVINEPSYRLNMHKLSHLHKDKPVKPLDSAIFWIEFVMRHKGAAHLRTESYKM 508

  Fly   487 KFVARNNLDV----YGVVLLVSLLLIVTIKFL 514
            .:.:.:::||    :.|||:::..:.||:::|
Zfish   509 PWYSYHSVDVVVTLFAVVLILTYCIFVTVRYL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	145/507 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	131/469 (28%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	153/530 (29%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	93/246 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585124
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740