Protein Alignment Ugt37E1 and UGT2B17

DIOPT Version :9

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 159/573 - (27%)
• Similarity: 269/573 - (46%)
• Gaps: 100/573 - (17%)

  Fly     9 FLIAFLLSTMT--QSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKL--ATH 69
            ::..|||..::  .|||....:.|:.|.. ||.|....:::.|..|||.:.|:|.....|  |:.
Human     5 WMSVFLLMQLSCYFSSGSCGKVLVWPTEY-SHWINMKTILEELVQRGHEVIVLTSSASILVNASK 68

  Fly    70 ENITVIIAPPTEERQRYIKEYMAEV------SNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNV 128
            .:...:...||...:..::::..::      |..|.:||...       |...|..:|:..: |:
Human    69 SSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYF-------SQLQELCWEYSDY-NI 125

  Fly   129 K---EIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISW---VGIPLPFMDTIVG 180
            |   :...|.|:       |||::....:....:| :|..|..|.:.|.   ||.      |:..
Human   126 KLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGEL-LAELLNIPFLYSLRFSVGY------TVEK 183

  Fly   181 N----VNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDY--------KMNQFYE 233
            |    :..|||||.|...|:   ..|.|..|..|.       ::....|:        |.:|||.
Human   184 NGGGFLFPPSYVPVVMSELS---DQMIFMERIKNM-------IYMLYFDFWFQAYDLKKWDQFYS 238

  Fly   234 RAFANELEFPNYHEMKRRVSLLFYNYHSAS----------EGPIRPTVPQSIEIGGIQVKEQADP 288
                         |:..|.:.||.....|.          |.| ||.:|....:||:..| .|.|
Human   239 -------------EVLGRPTTLFETMGKAEMWLIRTYWDFEFP-RPFLPNVDFVGGLHCK-PAKP 288

  Fly   289 LPKELAKFLDKADE-GAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLK-NKPGNA 351
            ||||:.:|:..:.| |.:.||||:.:  :....::.:::...|:::||:|:|:::..| |..|:.
Human   289 LPKEMEEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSN 351

  Fly   352 SNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGR 416
            :.::  .||||:|:|.||.||.||||.|..|:.||.|||:|||.:|:|.||..|...|...|...
Human   352 TRLY--KWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAAL 414

  Fly   417 WLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQS 481
            .:||.||:..:|...::.|:.:|.|:|.|.|.|.::.|:|:......::|.|:|:||:||.||:.
Human   415 SVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRV 479

  Fly   482 PLIHTKFVARNNLDVYGVVL--LVSLLLIVT--IKFLFRKILNVAIGYGSQRK 530
            ...:..::..::|||...:|  :.:::.::|  ..|.|||:...    |.::|
Human   480 AAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKT----GKKKK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	144/512 (28%)
		YjiC	27..448	CDD:224732	129/465 (28%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	148/538 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740