Protein Alignment Ugt37E1 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 156/554 - (28%)
• Similarity: 265/554 - (47%)
• Gaps: 73/554 - (13%)

  Fly     2 IEYTKIGFLIAFLLSTMT--QSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKP 64
            :::|.:     |||..::  .|||....:.|:.|.. ||.|....:::.|..|||.:||:|....
Human     3 LKWTSV-----FLLIQLSCYFSSGSCGKVLVWPTEY-SHWINMKTILEELVQRGHEVTVLTSSAS 61

  Fly    65 KL--ATHENITVIIAPPTEERQRYIKEYMAEVSN------EKPSFWETMVKAIVQSSNQLEGQYE 121
            .|  |:..:...:...||...:.|:::.:.::.:      .|.:||...       |...|..:|
Human    62 TLVNASKSSAIKLEVYPTSLTKNYLEDSLLKILDRWIYGVSKNTFWSYF-------SQLQELCWE 119

  Fly   122 FMTHPN--VKEIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISW-VGIPLPFMD 176
            :..:.|  .|:...|.|:       |||::....:....:| :|.....|.:.|. ..:...|..
Human   120 YYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGEL-LAELFNIPFLYSLRFSVGYTFEK 183

  Fly   177 TIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDY-KMNQFYERAFANEL 240
            ...|.:..|||||.|...|:   ..|.|..|..|.........:..:.|. |.:|||.
Human   184 NGGGFLFPPSYVPVVMSELS---DQMIFMERIKNMIHMLYFDFWFQIYDLKKWDQFYS------- 238

  Fly   241 EFPNYHEMKRRVSLLFYNYHSAS----------EGPIRPTVPQSIEIGGIQVKEQADPLPKELAK 295
                  |:..|.:.||.....|.          |.| ||.:|....:||:..| .|.|||||:.:
Human   239 ------EVLGRPTTLFETMGKAEMWLIRTYWDFEFP-RPFLPNVDFVGGLHCK-PAKPLPKEMEE 295

  Fly   296 FLDKADE-GAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLK-NKPGNASNIFFGN 358
            |:..:.| |.:.||||:.:  :....::.:::...|:::||:|:|:::..| |..|:.:.::  .
Human   296 FVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLY--K 356

  Fly   359 WLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTM 423
            ||||:|:|.||.||.||||.|..|:.||.|||:|||.:|:|.||..|...|...|....:||.||
Human   357 WLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTM 421

  Fly   424 TEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKF 488
            :..:|...::.|:.:|.|:|.:.|.|.::.|:|:......::|.|:|:||:||.||:....:..:
Human   422 SSRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTW 486

  Fly   489 VARNNLDVYGVVL--LVSLLLIVT--IKFLFRKI 518
            :..::|||...:|  :.:::.|:|  ..|.|||:
Human   487 IQYHSLDVIAFLLACVATVIFIITKFCLFCFRKL 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	130/471 (28%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	146/524 (28%)