Protein Alignment Ugt37E1 and Ugt1a8

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001365304.1
• Gene: Ugt1a8 / 613123
• MGIID: 3576090
• Length: 530
• Species: Mus musculus
• Alignment Length: 561
• Identity: 166/561 - (29%)
• Similarity: 268/561 - (47%)
• Gaps: 86/561 - (15%)

  Fly     6 KIGFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATH- 69
            ::..|:||.|:    .:|...::.:.|:|..|   :.|.|.| |:.|||.:.||.   |:::.|
Mouse    13 RVCLLLAFGLA----QAGRLLVVPMDGSHWFS---MKMIVEK-LSHRGHEVVVVI---PEVSWHL 66

  Fly    70 ---ENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTH------ 125
               :|.||         :.|...|..|..:...:|:     |..|..|:..|.:..:.|
Mouse    67 GKSQNFTV---------KTYSVSYTLEDLSHHFNFF-----AHKQWENREVGMFSLLKHSGKGFF 117

  Fly   126 ----PNVKEIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIV 179
                .:.:.::.:.|:       .||.|||... :...|.||.....|.::...||...::|...
Mouse   118 QVLFSHCRSLFNDKKLVEYLKQRSFDAVFLDPF-DVCGLTIAKYFSLPSVVFSGGIFCHYLDEGA 181

  Fly   180 GNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKY---AIMC--VFETVLDYKMNQFYERAFANE 239
            ...:.|||||.:   |:....||.|..|..|:|.|   ...|  .|:|.::          .|:|
Mouse   182 QCPSPPSYVPRI---LSKFADTMTFKERVWNYFSYMKERAFCPYFFKTAIE----------IASE 233

  Fly   240 -LEFP-NYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE 302
             |:.| ...::...||:..:......|.| ||.:|..:.||||.. ....||.||...:::.:.|
Mouse   234 VLQTPVTMTDLFSSVSIWMFRTDFVLEFP-RPVMPNMVYIGGINC-HPGKPLSKEFEAYVNASGE 296

  Fly   303 -GAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFGNWLPQDD 364
             |.:.||||:.|:.   .|:...: :.:.|.::||.|:|::..  .:|.| |.|.....||||:|
Mouse   297 HGIVVFSLGSMVSE---IPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQND 356

  Fly   365 ILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELE 429
            :|.||.|:.||||:|..|:.|...:|||||.:|:||||..||:.|...|.|..|::|.||..:||
Mouse   357 LLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLE 421

  Fly   430 QTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNL 494
            ..::.|:.|.:|:|.|.:.|:|::|||:......::|.|||:||:||.||:.......:...::|
Mouse   422 NALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSL 486

  Fly   495 DVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            ||.|.:|.:    ::|:.|:..|    ...||. ||....|
Mouse   487 DVIGFLLAI----VLTVVFIVFK----CCAYGC-RKCFGGK 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	138/471 (29%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	162/544 (30%)