Protein Alignment Ugt37E1 and UGT2A2

DIOPT Version :9

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 150/567 - (26%)
• Similarity: 256/567 - (45%)
• Gaps: 133/567 - (23%)

  Fly    10 LIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHEN--- 71
            ::.|.| |:|:.....|:| ::.|.. ||.:....:::.|..|.||:||:.. ...|..:.|
Human    16 MLVFNL-TLTEVVLSGNVL-IWPTDG-SHWLNIKIILEELIQRNHNVTVLAS-SATLFINSNPDS 76

  Fly    72 -ITVIIAPPTEERQRY--IKEYMAEV-SNEKP------SFWETMVKAI---VQSSNQL-EGQYEF 122
             :...:.|.:.::...  :.|:|..: .:.:|      :|::.:.|.:   .|.:.|| :|
Human    77 PVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDG---- 137

  Fly   123 MTHPNVKEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVIISW----VGIPLPFMDTI----- 178
                    :.:|||         |||...:.|....:..||.|..    :.:.:|||.|:
Human   138 --------VLKNPK---------LMARLQKGGFDVLVADPVTICGDLVALKLGIPFMYTLRFSPA 185

  Fly   179 ------VGNVNDP-SYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDY-------KMN 229
                  .|.:..| ||||   .||:.....|.||.|..|...|::.       ||       :.|
Human   186 STVERHCGKIPAPVSYVP---AALSELTDQMTFGERIKNTISYSLQ-------DYIFQSYWGEWN 240

  Fly   230 QFYERAFAN--------------------ELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQS 274
            .:|.:....                    :.|||                        ||.:|..
Human   241 SYYSKILGRPTTLCETMGKAEIWLIRTYWDFEFP------------------------RPYLPNF 281

  Fly   275 IEIGGIQVKEQADPLPKELAKFLDKADE-GAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVI 338
            ..:||:..| .|.|||||:.:|:..:.: |.:.||||:.|...|  .:..:::...|:::||:|:
Human   282 EFVGGLHCK-PAKPLPKEMEEFIQSSGKNGVVVFSLGSMVKNLT--EEKANLIASALAQIPQKVL 343

  Fly   339 WKWEDLKNKP---GNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFG 400
            |:::.  .||   ||.:.:|  :|:||:|:|.||.||.||||.|..|:.||.|||||||.:|:|.
Human   344 WRYKG--KKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFA 404

  Fly   401 DQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIY 465
            ||..|...|...|....:::.|||..:|...:|.|:..|:|:|...:.|.::.|:|:......::
Human   405 DQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVF 469

  Fly   466 WTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLL---VSLLLIV 509
            |.|:|:||:||.||:.......:...::|||.|.:|:   .::.|::
Human   470 WIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVI 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	140/528 (27%)
		YjiC	27..448	CDD:224732	127/484 (26%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	146/552 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150188
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740