DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	559	Identity:	155/559 - (27%)
Similarity:	246/559 - (44%)	Gaps:	103/559 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALAD----RGHNITVVTQMKPKLATHE 70
            |:...:.:.|.:   .|:|.:.|.:|      |...|:.:.|    |.|.:||:
Zfish    11 LVLIFIFSFTHA---GNVLVLPGEYS------HWQNMRNVVDELLNRNHTVTVL----------- 55

  Fly    71 NITVIIAPPT-----EERQRYIKEYMAEVSNEKPSFWETMVKAIVQ--SSNQLE---------GQ 119
               |..|.||     :||.:|:...:...:.|.....|.::....|  |.|:|:         |:
Zfish    56 ---VCSASPTINFTQQERFQYLVFEVPLSAQELDGASEELIHIWTQHPSPNRLQTALQIIELLGR 117

  Fly   120 YEFMTHPNVKEIYEN-------PKIKFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPF-MD 176
            ...|.......:..|       ..:|||::|...|.....| :|..|..|:::| |.|...| ::
Zfish   118 VRVMHRAMCDSMLRNDALIAQLSALKFDVLFNDPMFMCADL-LAEMLGLPLVLS-VRISPGFCLE 180

  Fly   177 TIVGNV-NDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMN-----QFYERA 235
            .:.|.: ..||:||.....|...                  ||..|.|.:...|     .||..|
Zfish   181 RMCGQMPAPPSFVPITQTVLTDR------------------MCFMERVQNMIANIVFSVSFYIVA 227

  Fly   236 FANELEFPNYH-----------EMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPL 289
            :   :...:|:           |...:..:.....:...|.| ||..|....:||:..| .|.||
Zfish   228 W---ISLDSYYTDVLGKPTTMCETMGKADIWLIRTYWDFEYP-RPFPPNFKFVGGLHCK-PAKPL 287

  Fly   290 PKELAKFLDKA-DEGAIFFSLGTNV-NTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNAS 352
            .||:.:|:..: |.|.:.||||:.: |..:.|.:|:   ...|.::||:|:|::.. |.....|.
Zfish   288 SKEMEEFVQSSGDHGVVVFSLGSMIKNLTSERANTI---AAALGQIPQKVVWRYSG-KTPETLAP 348

  Fly   353 NIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRW 417
            |....:|:||:|:|.||.||.||||.|..|:.||.|||||||.||:|.||..|...|...|....
Zfish   349 NTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVV 413

  Fly   418 LDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSP 482
            |||.|:...:|...::.||.||:|:|:|.:.|.::.|:|:......:||.|:|:|::||.||:..
Zfish   414 LDINTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQ 478

  Fly   483 LIHTKFVARNNLDVYGVVL----LVSLLLIVTIKFLFRK 517
            .....:...:.|||...:|    |::.|.:....||||:
Zfish   479 AHELSWYQYHCLDVAAFLLSIAALITFLWVKACCFLFRR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	141/511 (28%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	130/467 (28%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	153/544 (28%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	87/236 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910