DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt8

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	568	Identity:	150/568 - (26%)
Similarity:	235/568 - (41%)	Gaps:	107/568 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KIGFLIAFLLSTM-TQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHN-ITVVTQMKPKLAT 68
            |..|::|.||..: |..|..|.|:.|......||:.:...:..||...||: :.:|::.:.
Zfish     2 KAFFVLATLLWCLATSLSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHDTVFLVSEGRE---- 62

  Fly    69 HENITVIIAPPTEER-QRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTH--PNVKE 130
                   |.|....| |||...:.   |.....|.::.|:.|..........::.:.|  .|...
Zfish    63 -------IPPSNHYRLQRYPGIFN---STSADDFLQSKVRNIFSGRLTALELFDILDHYSQNCDA 117

  Fly   131 IYENPKI-------KFDLV--------------FLGLMANTYQLGIAAKLKCPVIISW----VGI 170
            :..:..:       .|||:              .||:....:..|:           |    ||.
Zfish   118 VVGSTSVMEQLKREHFDLLLVDPNEMCGFVIAHILGVQYAVFSTGL-----------WYPAEVGA 171

  Fly   171 PLPFMDTIVGNVNDPSYVPTVN------------VALNAGQKTMDFGLRFVNFFKYAIMCVFETV 223
            |.|.           ||||..|            ||..|......||::|:...||
Zfish   172 PAPL-----------SYVPEFNSLLTDHMSLFQRVANTAVYLVSRFGVQFLVLPKY--------- 216

  Fly   224 LDYKMNQFYERAFANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADP 288
             |..|.::      |.....:.|::.:...|.......|.|.| |||:|..:.:|||..|..: |
Zfish   217 -DRIMRKY------NIQPSVSMHDLVQNSRLWMLCTDMALEFP-RPTLPHVVYVGGILTKPPS-P 272

  Fly   289 LPKELAKFLDKADE-GAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGN-A 351
            ||:|...::...|| |.:..|.|..|  .....|....|...||:|||||||::..:  .|.| .
Zfish   273 LPQEFETWVKDTDEDGFVVVSFGAGV--KYLSDDIAQKLAGALSRLPQRVIWRFSGV--PPSNLG 333

  Fly   352 SNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGR 416
            :|....:|:||:|:|...||:.|::|.|...:.||.|||||:|.:|:|||.......:...|.|.
Zfish   334 NNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGI 398

  Fly   417 WLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQS 481
            .|:...|:|.:|...:..|:.:..|||.....|.:::|:|.......:||..|:|||:||.||:|
Zfish   399 MLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRS 463

  Fly   482 PLIHTKFVARNNLDVYGVVLLVSLLLIVTIKFLFR--KILNVAIGYGS 527
            .:..........||   |.:::.:.|::|...|:|  |.:...:|.||
Zfish   464 AVYEIPTYQYFLLD---VAMVIGVCLLLTGYCLYRIVKFIQFRLGRGS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	133/511 (26%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	117/463 (25%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	140/538 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585187
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840