Protein Alignment Ugt37E1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 164/559 - (29%)
• Similarity: 264/559 - (47%)
• Gaps: 82/559 - (14%)

  Fly     8 GFLIAFLLSTMT-QSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATH-- 69
            |.|:  |||... ..||...::.:.|    ||.:....|::.|..|||...|:|   |::..|
Human    15 GLLL--LLSVQPWAESGKVLVVPIDG----SHWLSMREVLRELHARGHQAVVLT---PEVNMHIK 70

  Fly    70 -ENI----TVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVK 129
             ||.    |..|:...:|..|::..: .::..|...|.:...:::...:|.     ..:.|.:..
Human    71 EENFFTLTTYAISWTQDEFDRHVLGH-TQLYFETEHFLKKFFRSMAMLNNM-----SLVYHRSCV 129

  Fly   130 EIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIP--LPFMDTIVGNVNDP 185
            |:..|..:       .||:| |....|.....:|..|..|.:.....||  |.|..|...|.:
Human   130 ELLHNEALIRHLNATSFDVV-LTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPS-- 191

  Fly   186 SYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYE--RAFANELEFPNYHEM 248
            ||:|.:   |......|.|..|..|.       ::...|.|..:.|..  .:.|:||       .
Human   192 SYIPRL---LTTNSDHMTFMQRVKNM-------LYPLALSYICHAFSAPYASLASEL-------F 239

  Fly   249 KRRVSLLFYNYHSA---------SEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-G 303
            :|.||::....|::         .:.| ||.:|..:.||||....: .||.:|...:::.:.| |
Human   240 QREVSVVDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANR-KPLSQEFEAYINASGEHG 302

  Fly   304 AIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFGNWLPQDDIL 366
            .:.||||:.|:.   .|:...: :...|.|:||.|:|::..  .:|.| |:|.....||||:|:|
Human   303 IVVFSLGSMVSE---IPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLL 362

  Fly   367 AHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQT 431
            .||.|:.||||||..||.|:..:|||||.:|:||||..||:.|...|.|..|::|.||..:||..
Human   363 GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENA 427

  Fly   432 IREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDV 496
            ::.|:.:.:|:|.|.:.|:|::|||:......::|.|:|:||:||.||:.......:...::|||
Human   428 LKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV 492

  Fly   497 YGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            .|.:|.|    ::|:.|:..|.  .|.||   ||.:..|
Human   493 IGFLLAV----VLTVAFITFKC--CAYGY---RKCLGKK 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	133/470 (28%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	158/543 (29%)