Protein Alignment Ugt37E1 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 164/559 - (29%)
• Similarity: 264/559 - (47%)
• Gaps: 82/559 - (14%)

  Fly     8 GFLIAFLLSTMT-QSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATH-- 69
            |.|:  |||... ..||...::.:.|    ||.:....|::.|..|||...|:|   |::..|
Human    15 GLLL--LLSVQPWAESGKVLVVPIDG----SHWLSMREVLRELHARGHQAVVLT---PEVNMHIK 70

  Fly    70 -ENI----TVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVK 129
             ||.    |..|:...:|..|::..: .::..|...|.:...:::...:|.     ..:.|.:..
Human    71 EENFFTLTTYAISWTQDEFDRHVLGH-TQLYFETEHFLKKFFRSMAMLNNM-----SLVYHRSCV 129

  Fly   130 EIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIP--LPFMDTIVGNVNDP 185
            |:..|..:       .||:| |....|.....:|..|..|.:.....||  |.|..|...|.:
Human   130 ELLHNEALIRHLNATSFDVV-LTDPVNLCAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCPNPS-- 191

  Fly   186 SYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYE--RAFANELEFPNYHEM 248
            ||:|.:   |......|.|..|..|.       ::...|.|..:.|..  .:.|:||       .
Human   192 SYIPRL---LTTNSDHMTFMQRVKNM-------LYPLALSYICHAFSAPYASLASEL-------F 239

  Fly   249 KRRVSLLFYNYHSA---------SEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-G 303
            :|.||::....|::         .:.| ||.:|..:.||||....: .||.:|...:::.:.| |
Human   240 QREVSVVDILSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINCANR-KPLSQEFEAYINASGEHG 302

  Fly   304 AIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFGNWLPQDDIL 366
            .:.||||:.|:.   .|:...: :...|.|:||.|:|::..  .:|.| |:|.....||||:|:|
Human   303 IVVFSLGSMVSE---IPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLL 362

  Fly   367 AHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQT 431
            .||.|:.||||||..||.|:..:|||||.:|:||||..||:.|...|.|..|::|.||..:||..
Human   363 GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENA 427

  Fly   432 IREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDV 496
            ::.|:.:.:|:|.|.:.|:|::|||:......::|.|:|:||:||.||:.......:...::|||
Human   428 LKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV 492

  Fly   497 YGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            .|.:|.|    ::|:.|:..|.  .|.||   ||.:..|
Human   493 IGFLLAV----VLTVAFITFKC--CAYGY---RKCLGKK 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	145/497 (29%)
		YjiC	27..448	CDD:224732	128/450 (28%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	158/543 (29%)
		egt	<262..508	CDD:223071	94/256 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150621
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H86211
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740