Protein Alignment Ugt37E1 and UGT1A1

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_000454.1
• Gene: UGT1A1 / 54658
• HGNCID: 12530
• Length: 533
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 153/570 - (26%)
• Similarity: 262/570 - (45%)
• Gaps: 102/570 - (17%)

  Fly     7 IGFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHEN 71
            :|.|:. :|..:...:|...::.|.|    ||.:..:..::.|..|||.|
Human    13 LGLLLC-VLGPVVSHAGKILLIPVDG----SHWLSMLGAIQQLQQRGHEI--------------- 57

  Fly    72 ITVIIAP-----------------PTEERQRYIKEYMAEVSN---EKPSFWETMVKA---IVQSS 113
              |::||                 |...::..:||....:.:   |..||.:.::|.   |.:.|
Human    58 --VVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS 120

  Fly   114 NQLEGQYEFMTHPNVKEIYEN-PKIKFDLVFLGLMANTYQLGIAAKLKC-PVIISWVGIPLPF-- 174
            ..|......:.|.  ||:..: .:..||:    ::.:.:       |.| |::..::.:|..|
Human   121 AMLLSGCSHLLHN--KELMASLAESSFDV----MLTDPF-------LPCSPIVAQYLSLPTVFFL 172

  Fly   175 ------MDTIVGNVNDP-SYVPTVNVALNAGQKTMDFGLRFVNF---FKYAIMC-VFETVLDYKM 228
                  ::.......:| ||||.   .|::....|.|..|..|.   |....:| |..:......
Human   173 HALPCSLEFEATQCPNPFSYVPR---PLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLA 234

  Fly   229 NQFYERAFANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKEL 293
            ::|.:|..       ...::....|:..:......:.| ||.:|..:.:|||....| :||.:|.
Human   235 SEFLQREV-------TVQDLLSSASVWLFRSDFVKDYP-RPIMPNMVFVGGINCLHQ-NPLSQEF 290

  Fly   294 AKFLDKADE-GAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIF 355
            ..:::.:.| |.:.||||:.|:.   .|:...: :...|.|:||.|:|::..  .:|.| |:|..
Human   291 EAYINASGEHGIVVFSLGSMVSE---IPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTI 350

  Fly   356 FGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDI 420
            ...||||:|:|.||.|:.||||||..||.|:..:|||||.:|:||||..||:.|...|.|..|::
Human   351 LVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNV 415

  Fly   421 LTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIH 485
            |.||..:||..::.|:.:.:|:|.|.:.|:|::|||:......::|.|:|:||:||.||:.....
Human   416 LEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD 480

  Fly   486 TKFVARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            ..:...::|||.|.:|.|    ::|:.|:..|.  .|.||   ||.:..|
Human   481 LTWYQYHSLDVIGFLLAV----VLTVAFITFKC--CAYGY---RKCLGKK 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	125/481 (26%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	150/554 (27%)