Protein Alignment Ugt37E1 and UGT1A4

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 167/562 - (29%)
• Similarity: 260/562 - (46%)
• Gaps: 88/562 - (15%)

  Fly     8 GFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALAD---RGHNITVVTQMKPKLATH 69
            |.|:  |||....:..| .:|.|....||     .:::.:||.:   |||...|:|   |::..|
Human    15 GLLL--LLSVQPWAESG-KVLVVPTDGSP-----WLSMREALRELHARGHQAVVLT---PEVNMH 68

  Fly    70 ------ENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWET--MVKAIVQSSNQLEGQYEFMTHP 126
                  ..:|....|.|:      ||:..........|:||  ::|...:|. .:........|.
Human    69 IKEEKFFTLTAYAVPWTQ------KEFDRVTLGYTQGFFETEHLLKRYSRSM-AIMNNVSLALHR 126

  Fly   127 NVKEIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIP--LPFMDTIVGNV 182
            ...|:..|..:       .||:| |....|.....:|..|..|.:..|..||  |.|..|...|.
Human   127 CCVELLHNEALIRHLNATSFDVV-LTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNP 190

  Fly   183 NDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYE--RAFANELEFPNY 245
            :  ||:|.:   |......|.|..|..|.       ::...|.|..:.|..  .:.|:||
Human   191 S--SYIPKL---LTTNSDHMTFLQRVKNM-------LYPLALSYICHTFSAPYASLASEL----- 238

  Fly   246 HEMKRRVSLL-FYNYHS--------ASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKAD 301
              .:|.||:: ..:|.|        ..:.| ||.:|..:.||||.. ....||.:|...:::.:.
Human   239 --FQREVSVVDLVSYASVWLFRGDFVMDYP-RPIMPNMVFIGGINC-ANGKPLSQEFEAYINASG 299

  Fly   302 E-GAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFGNWLPQD 363
            | |.:.||||:.|:.   .|:...: :...|.|:||.|:|::..  .:|.| |:|.....||||:
Human   300 EHGIVVFSLGSMVSE---IPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQN 359

  Fly   364 DILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHEL 428
            |:|.||.|:.||||||..||.|:..:|||||.:|:||||..||:.|...|.|..|::|.||..:|
Human   360 DLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDL 424

  Fly   429 EQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNN 493
            |..::.|:.:.:|:|.|.:.|:|::|||:......::|.|:|:||:||.||:.......:...::
Human   425 ENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHS 489

  Fly   494 LDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            |||.|.:|.|    ::|:.|:..|.  .|.||   ||.:..|
Human   490 LDVIGFLLAV----VLTVAFITFKC--CAYGY---RKCLGKK 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	137/474 (29%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	162/546 (30%)