Protein Alignment Ugt37E1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 163/564 - (28%)
• Similarity: 262/564 - (46%)
• Gaps: 92/564 - (16%)

  Fly     8 GFLIAFLLSTMT-QSSGGANILGVFGTHSPSHVIVHMAVMKALAD---RGHNITVVTQMKPKLAT 68
            |.|:  |||... ..||...::...|:|       .:::.:||.|   |||.:.|:|........
Human    15 GLLL--LLSVQPWAESGKVLVVPTDGSH-------WLSMREALRDLHARGHQVVVLTLEVNMYIK 70

  Fly    69 HENI----TVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLE--GQYEFMTHPN 127
            .||.    |..|:...:|..|.:       .....||:|| ...:::.|.::.  .....:.|.:
Human    71 EENFFTLTTYAISWTQDEFDRLL-------LGHTQSFFET-EHLLMKFSRRMAIMNNMSLIIHRS 127

  Fly   128 VKEIYENPKI-------KFDLVFLGLMANTYQL--GIAAK-LKCPVIISWVGIP--LPFMDTIVG 180
            ..|:..|..:       .||:|    :.:.:.|  .:.|| |..|.:.....||  |.|..|...
Human   128 CVELLHNEALIRHLHATSFDVV----LTDPFHLCAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCP 188

  Fly   181 NVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYE--RAFANELEFP 243
            |.:  ||:|.:   |......|.|..|..|.       ::...|.|..:....  .:.|:||
Human   189 NPS--SYIPRL---LTTNSDHMTFLQRVKNM-------LYPLALSYLCHAVSAPYASLASEL--- 238

  Fly   244 NYHEMKRRVSLLFYNYHSA---------SEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDK 299
                .:|.||::....|::         .:.| ||.:|..:.||||.. ....||.:|...:::.
Human   239 ----FQREVSVVDLVSHASVWLFRGDFVMDYP-RPIMPNMVFIGGINC-ANGKPLSQEFEAYINA 297

  Fly   300 ADE-GAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFGNWLP 361
            :.| |.:.||||:.|:.   .|:...: :...|.|:||.|:|::..  .:|.| |:|.....|||
Human   298 SGEHGIVVFSLGSMVSE---IPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLP 357

  Fly   362 QDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEH 426
            |:|:|.||.|:.||||||..||.|:..:|||||.:|:||||..||:.|...|.|..|::|.||..
Human   358 QNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE 422

  Fly   427 ELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVAR 491
            :||..::.|:.:.:|:|.|.:.|:|::|||:......::|.|:|:||:||.||:.......:...
Human   423 DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY 487

  Fly   492 NNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            ::|||.|.:|.|    ::|:.|:..|.  .|.||   ||.:..|
Human   488 HSLDVIGFLLAV----VLTVAFITFKC--CAYGY---RKCLGKK 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	144/502 (29%)
		YjiC	27..448	CDD:224732	127/455 (28%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	157/548 (29%)
		egt	<262..508	CDD:223071	94/256 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740