Protein Alignment Ugt37E1 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 162/568 - (28%)
• Similarity: 263/568 - (46%)
• Gaps: 91/568 - (16%)

  Fly    11 IAFLLSTMTQSSGGANILGVFG----------THSPSHVIVHMAVMKALADRGHNITVVT-QMKP 64
            :|.||.:..:.|.|...|.::|          ....||.:....:::.|:||||.|.||. ::..
Human     1 MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNL 65

  Fly    65 KLATHENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVK 129
            .|...:..|..|.|...:::        |:.|...||           .|....:..|:|.|..:
Human    66 LLKESKYYTRKIYPVPYDQE--------ELKNRYQSF-----------GNNHFAERSFLTAPQTE 111

  Fly   130 EIYENPKIKFDLVFLGLMA--------NTYQ------LGIAAKLKCPVIIS-WVGIPLPF----- 174
              |.|..|...|.|:...:        |.::      |.....|.|.||:: ::|:|..:
Human   112 --YRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGF 174

  Fly   175 ---MDTIVGNVNDP-SYVPTVNVALNAGQKTMDFGLRFVNFF-----KYAIMCVFETVLDYKMNQ 230
               ::.......|| ||:|......:   ..|.|..|..||.     .|...|:|.     |..:
Human   175 PCSLEHTFSRSPDPVSYIPRCYTKFS---DHMTFSQRVANFLVNLLEPYLFYCLFS-----KYEE 231

  Fly   231 FYERAFANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAK 295
            ........:::....::   :||:....|....|.| ||.:|..:.||||..|::.| |.:|...
Human   232 LASAVLKRDVDIITLYQ---KVSVWLLRYDFVLEYP-RPVMPNMVFIGGINCKKRKD-LSQEFEA 291

  Fly   296 FLDKADE-GAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFG 357
            :::.:.| |.:.||||:.|:.   .|:...: :...|.|:||.|:|::..  .:|.| |:|....
Human   292 YINASGEHGIVVFSLGSMVSE---IPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILV 351

  Fly   358 NWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILT 422
            .||||:|:|.||.|:.||||||..||.|:..:|||||.:|:||||..||:.|...|.|..|::|.
Human   352 KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLE 416

  Fly   423 MTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTK 487
            ||..:||..::.|:.:.:|:|.|.:.|:|::|||:......::|.|:|:||:||.||:.......
Human   417 MTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLT 481

  Fly   488 FVARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            :...::|||.|.:|.|    ::|:.|:..|.  .|.||   ||.:..|
Human   482 WYQYHSLDVIGFLLAV----VLTVAFITFKC--CAYGY---RKCLGKK 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	143/506 (28%)
		YjiC	27..448	CDD:224732	128/463 (28%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	150/533 (28%)
		UDPGT	27..523	CDD:278624	155/542 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740