Protein Alignment Ugt37E1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 161/567 - (28%)
• Similarity: 254/567 - (44%)
• Gaps: 104/567 - (18%)

  Fly    11 IAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVV-TQMKPKLATHENITV 74
            :..||:.....:|...::.:.|    ||.....:|::.|..|||.:.|| .::..:|....|.||
Human    14 VCLLLTCGFAEAGKLLVVPMDG----SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNCTV 74

  Fly    75 IIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYE------------FMTHPN 127
                     :.|...|..|..|.     |.||.|..|...|.:..:.            |.:|
Human    75 ---------KTYSTSYTLEDQNR-----EFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSH-- 123

  Fly   128 VKEIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWVGI-----------PLPF 174
            .:.::.:.|:       .||.|||... :|..|.:|.....|.::...||           |.|.
Human   124 CRSLFNDRKLVEYLKESSFDAVFLDPF-DTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPL 187

  Fly   175 MDTIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANE 239
                       ||||.   .|......|.|..|           |:..::..:.:.|.:..|.|.
Human   188 -----------SYVPN---DLLGFSDAMTFKER-----------VWNHIVHLEDHLFCQYLFRNA 227

  Fly   240 LEFPN--------YHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKF 296
            ||..:        .:::....|:.........:.| :|.:|..|.||||.. .|..|||.|...:
Human   228 LEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYP-KPVMPNMIFIGGINC-HQGKPLPMEFEAY 290

  Fly   297 LDKADE-GAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKWEDLKNKPGN-ASNIFFGN 358
            ::.:.| |.:.||||:.|:.   .|:...: :...|.|:||.|:|::..  .:|.| |:|.....
Human   291 INASGEHGIVVFSLGSMVSE---IPEKKAMAIADALGKIPQTVLWRYTG--TRPSNLANNTILVK 350

  Fly   359 WLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTM 423
            ||||:|:|.||.|:.||||||..||.|:..:|||||.:|:||||..||:.|...|.|..|::|.|
Human   351 WLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEM 415

  Fly   424 TEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKF 488
            |..:||..::.|:.:.:|:|.|.:.|:|::|||:......::|.|:|:||:||.||:.......:
Human   416 TSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW 480

  Fly   489 VARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            ...::|||.|.:|.|    ::|:.|:..|.  .|.||   ||.:..|
Human   481 YQYHSLDVIGFLLAV----VLTVAFITFKC--CAYGY---RKCLGKK 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	134/482 (28%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	159/555 (29%)