Protein Alignment Ugt37E1 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 152/539 - (28%)
• Similarity: 252/539 - (46%)
• Gaps: 92/539 - (17%)

  Fly    21 SSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENITVIIAP------- 78
            |||....:.|: |...||.:....::|.|..|||.:||:.         .:.:::..|
Human    19 SSGSCGKVLVW-TGEYSHWMNMKTILKELVQRGHEVTVLA---------SSASILFDPNDAFTLK 73

  Fly    79 ----PTE----ERQRYIKEYMAEVSN-EKPSFWETMVKAIVQSSNQLEGQYEF--MTHPNVKEIY 132
                ||.    |.:..|.:.:...|: :|.|||       :..|.:.|..:||  :.....|::.
Human    74 LEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFW-------LYFSQEQEILWEFHDIFRNFCKDVV 131

  Fly   133 ENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGN-VNDPSYVP 189
            .|.|:       :||::|........:| :||.|..|.:.|....|...::...|. :..|||:|
Human   132 SNKKVMKKLQESRFDIIFADAFFPCGEL-LAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIP 195

  Fly   190 TVNVALNAGQ------KTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFPNYHEM 248
            .|...|:...      |.|.:.|.|..:|:   ||..:     |.:|||.             |:
Human   196 VVMSKLSDQMTFMERVKNMIYVLYFDFWFQ---MCDMK-----KWDQFYS-------------EV 239

  Fly   249 KRRVSLLFYNYHSASEGPIR---------PTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-G 303
            ..|.:.||.....|....:|         |.:|....:||:..| .|.|||||:.:|:..:.| |
Human   240 LGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCK-PAKPLPKEMEEFVQSSGENG 303

  Fly   304 AIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKP---GNASNIFFGNWLPQDDI 365
            .:.||||:.::..|  .:..:::...|:|:||:|:|:::.  |||   |..:.::  .|:||:|:
Human   304 VVVFSLGSVISNMT--AERANVIATALAKIPQKVLWRFDG--NKPDALGLNTRLY--KWIPQNDL 362

  Fly   366 LAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQ 430
            |..|.|:.||||.|..|:.||.|||:|||.:|:|.||..|...|...|....||..||:..:|..
Human   363 LGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLN 427

  Fly   431 TIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLD 495
            .::.|:.:|:|:|.:.|.|.:..|:|:......::|.|:|:.|:||.||:.......:...::||
Human   428 ALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLD 492

  Fly   496 VYGVVL-LVSLLLIVTIKF 513
            |.|.:| .|:.::.|..||
Human   493 VIGFLLACVATVIFVVTKF 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	132/485 (27%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	149/534 (28%)