DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt35C1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001097744.1	Gene:	Ugt35C1 / 53507	FlyBaseID:	FBgn0040256	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	164/534 - (30%)
Similarity:	256/534 - (47%)	Gaps:	39/534 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENITVIIAPP 79
            ||.....|..|.||........|..|...:.:||||.:||.:||:...|.|  ...|:..|.|..
  Fly    14 LSAKPLESESAKILATLPFPGRSQYIFVESYLKALAAKGHQVTVINAFKNK--ETPNMRFIEALK 76

  Fly    80 TEERQRYIKEYMAEVSNEKPSFWETM------VKAIVQSSNQLEGQYEFMTHPNVKEIYENPKIK 138
            ..|   :..|.|:.::  .|..|:.:      :...:..:.:.||....:          |....
  Fly    77 AHE---FADEMMSLLN--VPLLWQQLNAMDYILNKFIDVTMEDEGVQRLL----------NSGET 126

  Fly   139 FDLVFLGLMANTYQLGIAAKLKCPVI-ISWVGIPLPFMDTIVGNVNDPSYVPTVNVALNAGQKTM 202
            ||||...::........|......:: .|..|.... :|...||::..||.|.|.   :.....|
  Fly   127 FDLVLAEMLHMEPMYAFAQHFNATLVGFSSFGTDRT-IDEAAGNISPISYNPLVT---SPRTDRM 187

  Fly   203 DFGLRFVNFFKYAIMCVFETVLDY-KMNQFYERAFANELEFPNYHEMKRRVSLLFYNYHSASEGP 266
            .|..|..|.::..:..:....:.. .|...|::.|.|..:  ...|:....||:....|.:...|
  Fly   188 TFLERLENHYEVIVEDIHRHFVHLPHMRNVYKKYFPNAKK--TLEEVMDSFSLILLGQHFSLSYP 250

  Fly   267 IRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGTNVNTNTFRPDTVDILYKVLS 331
             ||.:|..||:||:.:..:..|||:::.:|::.:..|.|:||:|:||.:.....:|.|.|.|..:
  Fly   251 -RPYLPNMIEVGGMHISHKPKPLPEDIKQFIEGSPHGVIYFSMGSNVKSKDLPQETRDTLLKTFA 314

  Fly   332 KLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVAL 396
            ||.|||:||:|| .:.||..:|:....|.||.|||||||.||||:|.|.....|:.|.|.|::.|
  Fly   315 KLKQRVLWKFED-DDMPGKPANVLIKKWYPQPDILAHPNVKLFISHGGLLSSTESVYFGKPILGL 378

  Fly   397 PIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQ 461
            |.|.||..|.:...:.|||..||:..:.:.:||:.|:.:|.:|:|.:.....|..|||:|.:|..
  Fly   379 PCFYDQHMNVQRAQRVGFGLGLDLNNLKQEDLEKAIQTLLTDPSYAKASLAISERYRDQPQSAVD 443

  Fly   462 SVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYG 526
            ..::|||||:||.||.||::......|:..|:||...|:|.|.|||.:.|..|..|:|.     |
  Fly   444 RAVWWTEYVIRHNGAPHLRATSRDLNFIQLNSLDTLAVILAVPLLLALLIVTLSCKLLG-----G 503

  Fly   527 SQRKAV-ANKLKNN 539
            .::|.: |:|||.:
  Fly   504 KKQKCLHADKLKKH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	140/467 (30%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	123/428 (29%)
Ugt35C1	NP_001097744.1	egt	1..470	CDD:223071	144/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.920