DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	177/559 - (31%)
Similarity:	272/559 - (48%)	Gaps:	73/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVT--QMKPKLATHENI 72
            |:..||..:.:   ||.|||||...|.||....:..:|.||..||.||.|:  .:|..:|...:|
  Fly    13 LVVALLPVLLE---GARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVANIHDI 74

  Fly    73 TVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLE--GQY------EFMTHPNV- 128
                  |..|....|:|.:..::|.|.: |           |:.|  .||      :.:.:..|
  Fly    75 ------PVPELFDNIEEIVGNLTNRKGT-W-----------NEFEYINQYTLGLVEKVLENDGVR 121

  Fly   129 KEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVI------ISWVGIPLPFMDTIVGNVNDPSY 187
            :||.:...::|||:.:.|.......|:||....|:|      ..|.      :|.:||||:..:|
  Fly   122 REILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWK------IDELVGNVSPLAY 180

  Fly   188 V--PTVNVALNAGQKTMD-FGLRFVNFFKYAIMCV-FETVLDYKMNQFYERAFANELEFPNYHEM 248
            :  |:.|      ...:| :|.|..:|...::..: :....:.:....|.:.|....:..:..|:
  Fly   181 LQSPSFN------WFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEI 239

  Fly   249 KRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-GAIFFSLGTN 312
            .|..:|:..|.| .:..|.||.||..||:||:.|.:|...||::|..|:..|.| |.|:||||||
  Fly   240 TRNFALILVNQH-FTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTN 303

  Fly   313 VNTNTFRPDTVDILYKVLSKLPQRVIWKW--EDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFI 375
            |.:.....|...||....:.||||::||:  ::|.:.|   ||:....|.||.|||||||.||||
  Fly   304 VRSRNLSKDRRKILIDTFASLPQRILWKFDADELSDVP---SNVLISPWFPQQDILAHPNVKLFI 365

  Fly   376 THAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPA 440
            ||.|.....|..:.||||:.||.|.||..|.|.:...|.|..|:...||..|.:.||.::|...:
  Fly   366 THGGLQSTVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKS 430

  Fly   441 YRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLL--- 502
            :.....:.:..|||:|:....:.|:||.|||||:||.|::....:..|:..::|||.|..||
  Fly   431 FGVKAKRTADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVW 495

  Fly   503 --VSLLLIVTIKFLFRKILNVAIGYGSQRKAVANKLKNN 539
              :|::::..|| |.|.||.      |::..::.|.|.|
  Fly   496 AILSIVVLCAIK-LLRAILK------SKKGNISPKQKIN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	156/488 (32%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	139/444 (31%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	157/494 (32%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	139/447 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445763
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850