DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt303A1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	147/537 - (27%)
Similarity:	251/537 - (46%)	Gaps:	55/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GFLIAFLLSTM--TQSSGGANILGVFG-THSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATH 69
            |.|:..||..:  .:.:...|||.||. |...|:::: ...::.|..|||.:|:::.:  .:..|
  Fly     9 GLLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLI-TPFLRNLVQRGHQLTLISAV--TIMPH 70

  Fly    70 -ENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEF------MTHPN 127
             |.:..|..|..:...:.:.::..:....|   |         :..|...:|.:      :..|.
  Fly    71 IEGVHHIRVPKLDMLMKILLDFEYDTDLTK---W---------TEAQFLSEYFYNCSKFVLEDPG 123

  Fly   128 VKEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVI------ISWVGIPLPFMDTIVGNVNDPS 186
            |:|:..|...|:.|:.|....|....|.:.....|::      .||      .:|.:|||.....
  Fly   124 VQELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSW------NIDFLVGNSAPSV 182

  Fly   187 YVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLD---YKMNQ--FYERAFANELEFPNYH 246
            |.|...:...:       ||..:..:...|....|.:::   |...|  .|::.|....  .:.|
  Fly   183 YEPMSALGYTS-------GLNLIEKWHNLIYITEERLVERFIYLPRQIDLYKQHFPGAT--TSIH 238

  Fly   247 EMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGT 311
            :::||.||:..|.| .:.|.:|..||..:|:.|:.:.|:..||..||.|.||:|:.|.|:||:|.
  Fly   239 DLRRRFSLVLINQH-FTMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDEAEHGVIYFSMGL 302

  Fly   312 NVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFIT 376
            .:..:...|.....:....::|.|:|||| .|.......:.|:|...|.||..||.|||.|||||
  Fly   303 QLLDHWLPPGMRASMSDAFAQLKQQVIWK-TDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFIT 366

  Fly   377 HAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAY 441
            |||...:.|:.::.||::.:|:|.||..|.:.|.|.|..|.||...:...|:...|.:::.|.:|
  Fly   367 HAGLLSLIESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASY 431

  Fly   442 RETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVL-LVSL 505
            :......|..:.|:|::|..:.|:||||:|||:||.|::........:...|:||..|:. .:.|
  Fly   432 KRNARDLSQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGL 496

  Fly   506 LLIVTIKFLFRKILNVA 522
            ..|:.| ||..|::::|
  Fly   497 SAIIVI-FLGWKLVSLA 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	133/487 (27%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	116/439 (26%)
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	129/470 (27%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	135/500 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445756
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850