DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt302K1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001287281.1	Gene:	Ugt302K1 / 53502	FlyBaseID:	FBgn0040251	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	160/545 - (29%)
Similarity:	262/545 - (48%)	Gaps:	46/545 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVT---QMKPKLATHEN 71
            ||..||.::..|| |.|.|.|..:...||..|..|:.|.|...||.||||:   |.|| :..:.:
  Fly     6 LILGLLCSLGYSS-GYNYLMVLNSAGRSHFNVGHALAKGLVKAGHTITVVSVFPQKKP-IPGYTD 68

  Fly    72 ITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIYENPK 136
            ::|             ...:..:..:..:.|.::.|...|:   |...|: |.....:.::|:..
  Fly    69 VSV-------------PNVIEVMGGDIGALWASIQKTYTQN---LIDHYQ-MGFRITRGLFEDSN 116

  Fly   137 IK--------FDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGNVNDPSYVPTVNV 193
            .:        ||.:......|....|:|.....|:|....|..|.|:..:||:....|:||.:.:
  Fly   117 FQDFLKSNQSFDAIICETFYNDAHYGLAEHFNAPLIGLATGGGLTFITDMVGSPAPASFVPHIML 181

  Fly   194 ALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFPN----YHEMKRRVSL 254
            ..|      |....:......|.:.....:|||......|:.:..  .||.    :::|:|..||
  Fly   182 PFN------DHMSLYERLLNVAFLGYERVLLDYYFLPTQEKLYKE--FFPGNKRCFYKMRRNASL 238

  Fly   255 LFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGTNVNTNTFR 319
            :..|.|.:...| ||..|..||:||:.:..:.:|||:::.:|:::::.|||:||:|:|:.|....
  Fly   239 VLINQHVSLSFP-RPHSPNMIEVGGMHIDGKWNPLPEKIERFINESEHGAIYFSMGSNLKTKDLP 302

  Fly   320 PDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVA 384
            |..|..:.|.|..|.|||:||:| |.|.|....|::..:|.||.||||||....|:||.|.....
  Fly   303 PSKVQEILKALGGLKQRVLWKFE-LDNLPNKPENVYISDWFPQTDILAHPKIMAFVTHGGMLSTT 366

  Fly   385 EAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFS 449
            |:.||..|::.||||.||..|.....::|:|..||..|:...|..:.|..:...|:|.:.:...|
  Fly   367 ESIYHAKPVIGLPIFSDQFFNMAHAEQNGYGIMLDFKTLNAVEFRKAIERITSEPSYTKVVQGIS 431

  Fly   450 TLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIVTIKFL 514
            ..|||:..|..::.|||.|:|.|||||.:|:|......:...:|:||..::.:|.:||::.:...
  Fly   432 FRYRDQQQTPIENAIYWVEHVTRHQGAAYLKSAAQRLNWWQYHNVDVLLIIFVVMVLLLIVLPIT 496

  Fly   515 FRKILNVAIGYGSQRKAVANKLKNN 539
            ..|:|...:..|.:.:  :.|:|.|
  Fly   497 IYKLLKKLLLKGERTQ--STKVKRN 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	143/479 (30%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	123/435 (28%)
Ugt302K1	NP_001287281.1	egt	1..480	CDD:223071	151/502 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445757
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850