DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt36A1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	154/560 - (27%)
Similarity:	261/560 - (46%)	Gaps:	69/560 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GFLIAFLLSTM--TQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMK-PKLATH 69
            |.||..||..:  .:.....|||.|:.....||..|.|.::..||.|||:|||::.:| |:...:
  Fly     8 GVLIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAY 72

  Fly    70 EN---------------ITVIIAP-----PTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSN 114
            .|               .|:.:.|     ||......|:||: ::..|.....|.:.     :|.
  Fly    73 PNYEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYV-DLHEEGQKTCEHLF-----ASG 131

  Fly   115 QLEGQYEFMTHPNVKEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVI-ISWVGIPLPFMDTI 178
            .:|...|  .|.|      .|   :||:......:..||.:|..|..|:| :|...: :|:....
  Fly   132 HIERAIE--RHRN------KP---YDLLLTEYFNSDCQLALAKLLNLPIIGLSTCAL-MPYYYDR 184

  Fly   179 VGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANEL--- 240
            :...:.|:::.:..|.. |||  :::..|.:||.:..::...     ||   ::.....|||
  Fly   185 IDLPDTPAFIQSEFVGF-AGQ--LNWHERLLNFVQAKLLKFL-----YK---YHSNRADNELVRK 238

  Fly   241 ----EFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQAD-PLPKELAKFLDKA 300
                |.......:.:.:.:|.|.|.:..|. ||...|.:||||:.:.::|: .||:.:|.||:::
  Fly   239 YLGVEVDVEEVARTQTAFIFGNQHYSLMGS-RPQSLQFVEIGGVHITKKAEQELPQNIANFLNQS 302

  Fly   301 DEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDI 365
            .||.||.|.|:.|..::...|.:..:.:||...|.::|||||..:....:||...|..|.||..:
  Fly   303 AEGVIFISWGSMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTDASKFLFVKWAPQLAL 367

  Fly   366 LAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQ 430
            |.||..|||.:|.|..|..|:.:.|.|::..||:|||..||..:...|.|..||...:|...|::
  Fly   368 LCHPKVKLFWSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKK 432

  Fly   431 TIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQ--GALHLQSPLIHTKFVARNN 493
            .:.|:..| :|.:...:.|.::.:|..|..:|.|:..|:|:.:.  .|..||||.|.......::
  Fly   433 ALAELSKN-SYAQRSLEVSKVFNERQQTPLESAIWSVEHVISNGLIAARLLQSPGIELNGFVYHS 496

  Fly   494 LDVYGVVLLVSLLLIVTIKFLFR----KILNVAIGYGSQR 529
            ||...::||..:|||:.:.:|.:    |:.:..:|...:|
  Fly   497 LDSVALILLPLILLILVLCYLCKRNPSKLAHKKVGKKPKR 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	137/500 (27%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	124/450 (28%)
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	137/497 (28%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	136/493 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454678
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	5.940