DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	172/548 - (31%)
Similarity:	256/548 - (46%)	Gaps:	80/548 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENIT 73
            ||:..||...::   ||.||.||...|.||....:..:|:||..||.||.|:.. |:.....||.
  Fly     5 FLLVCLLPGYSE---GARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPY-PQREPFRNIH 65

  Fly    74 VIIAPPTEERQRYIKEYMAEVSNEKPSFWET----------MVKAIVQSSNQLEGQYEFMTHPNV 128
            .|..|...|....:    ..:::...|.|::          :.|.::.:    ||..
  Fly    66 DIPVPEVFENFNEV----LRIASTPRSTWQSSDFINEYVLNLTKTVLNN----EGVR-------- 114

  Fly   129 KEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVI------ISWVGIPLPFMDTIVGNVNDPSY 187
            ::|....|..||||.:.|.......|:||....|:|      ..|.      :|.::|||:..||
  Fly   115 RDILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWK------IDELMGNVSPISY 173

  Fly   188 VPTVNVALNAGQKTMDFGLRFVNFFKYA--IMCVFETVLDY---------KMNQFYERAFANELE 241
            :.:.:             .||.:...|.  ::.:.|....|         |....|.:.|.:..|
  Fly   174 LQSPS-------------SRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAE 225

  Fly   242 FPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-GAI 305
            .....|:.|...|:..|.| .:.||.||.||..|::||:.|....:.|..||..|:..|.| |.|
  Fly   226 RKPLSEISRNFDLVLVNQH-FTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVI 289

  Fly   306 FFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPN 370
            :|||||||.:.:...|...:|.:..:.||||::||:|| :..||...|:|...|.||..||||||
  Fly   290 YFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFED-ELLPGKPPNVFISKWFPQQAILAHPN 353

  Fly   371 TKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREV 435
            .||||||.|.....|:.:||.||:.||...||..|.:.:.:.|.|..|:|..||..|...||..:
  Fly   354 VKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRL 418

  Fly   436 LGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVV 500
            |.|.::.||....:..|||:|:...::.|:||||||.|:||.|:|.......||..::|||:|..
  Fly   419 LTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTF 483

  Fly   501 L--------LVSLLLIVTIK---FLFRK 517
            |        :|:.||::|::   ||.::
  Fly   484 LVGALVILGIVTYLLVMTLRKCLFLIKR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	155/493 (31%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	137/448 (31%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	157/497 (32%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	161/518 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445764
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850