DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	148/538 - (27%)
Similarity:	248/538 - (46%)	Gaps:	96/538 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQM-KPKLATHENITVIIAPPTEERQRYIK 88
            |||||:|.....|...|...:::.||.||||:|::|.: .|.  ..|.:..|......||   ||
  Fly    24 ANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPN--DIEGVRHIRVAQLNER---IK 83

  Fly    89 EYMAEVSNEKPSFWETMV----------KAIVQSSNQLEGQYEFMTHPNVKEIYENPKIKFDLVF 143
            |.:     |.....:.|:          ||:..:||      :.::.|.|:.:..:....|||:.
  Fly    84 EML-----ESDQVLDFMINKWTESALTAKALFNASN------DILSDPGVQRMLHDKSESFDLII 137

  Fly   144 L---------GLMA--NTYQLGIAAKLKCPVIISW-----VGIPLPFMDTIVGNVNDPSYVPTVN 192
            :         ||:.  |...:|:::     :.|:|     .|.|.|       ::.:|  :..|.
  Fly   138 MEPSSLDALYGLVEFYNATLMGLSS-----IRINWHTYELAGNPAP-------SIYEP--ISPVG 188

  Fly   193 VALNAGQKTMDFGL------RFVNF--FKYAIMCVFETVLDY---KMNQFYERAFANELEFPNYH 246
            .:|.....:..:..      :.||:  .:.|.:.:|:....|   |||
  Fly   189 FSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQKMN----------------- 236

  Fly   247 EMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGT 311
            |::.|.||:..|.| .|.|.:|...|..||:||:.:.|..:|..:||.|||||||.|.|:||:|.
  Fly   237 ELRSRFSLMLINSH-YSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGN 300

  Fly   312 NVNTNTFRPDTV-DILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFI 375
            ::... |.|:.: ::|.:..:.|.:.:||| .:|...|..:.|::.....||..||.|||.:|||
  Fly   301 DILIK-FLPENIQELLLQTFATLNESIIWK-SELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFI 363

  Fly   376 THAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPA 440
            |:.|...|.||...||||:.||:|.||.||...:..||....:||.::.:..|.:||:.:|.|.:
  Fly   364 TNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNS 428

  Fly   441 YRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDV-------YG 498
            |.....:.|..::|||::...:.::||||.||::....::..|.....:....:|.       :|
  Fly   429 YYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFG 493

  Fly   499 VVLLVSLLLIVTIKFLFR 516
            :|....:.|:.|:...:|
  Fly   494 LVAASLIFLVYTLFLKYR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	141/488 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	129/459 (28%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	141/487 (29%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	139/519 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445762
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850