DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt303B3

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	155/548 - (28%)
Similarity:	249/548 - (45%)	Gaps:	94/548 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FLLSTMTQSS-GGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENITVII 76
            ||...:.|.| ..|||||:|..|..||.:|...:.|||..||||:|::|.              :
  Fly    15 FLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITP--------------V 65

  Fly    77 APPTE-ERQRYIK--------EYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIY 132
            ..||: |..|:|:        :.|.|.......|....:.:::..|.......:.::...|:::.
  Fly    66 GMPTDIEGVRHIRVPKLNQRVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGVQKML 130

  Fly   133 ENPKIKFDLVFLGLMANTYQLGIAAKLKCPVI------ISWVGIPLPFMDTIVGNVNDPSYVPTV 191
            :|...:||||.|...|.....|:.......::      ::|      ..:.:.||     :.|::
  Fly   131 QNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNW------STEEVAGN-----FAPSI 184

  Fly   192 NVALNAGQKTMDFGL--RFVNF-------------FKYAIMCVFETVLDYKMNQFYERAFANELE 241
            |..:::...:....|  :..|:             |:.:.:.:|:...::...:||
  Fly   185 NDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFY--------- 240

  Fly   242 FPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIF 306
                 .|:.:.|::..|.| .|.|.:|..||..||:||:.:.|.|:|...:|.||:|.|:.|.|:
  Fly   241 -----NMREKYSVILVNNH-ISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDAEHGVIY 299

  Fly   307 FSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNASNIFFGNWLPQDDILAHPNT 371
            ||:|..:.......|....|.|.|.:..|||:||.| |.|.|..:.|::.....||..:||||||
  Fly   300 FSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTE-LYNMPNKSDNVYVIEQPPQRAVLAHPNT 363

  Fly   372 KLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVL 436
            :||||:.|...|.||.|.|||::.||:|.||..|...:...|....||...||...|..|||::|
  Fly   364 RLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLL 428

  Fly   437 GNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDV----- 496
            .||.|.....|.|..:||||::...:.::||||.||::.|.|::          .|..||
  Fly   429 ENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMR----------LNTEDVPLYYE 483

  Fly   497 --YGVVL-----LVSLLLIVTIKFLFRK 517
              :|::|     :|...:|..:..||:|
  Fly   484 WDWGLLLGLRFGIVFGSVIYLVYKLFQK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	143/492 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	125/450 (28%)
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	143/491 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445754
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850