DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	179/550 - (32%)
Similarity:	277/550 - (50%)	Gaps:	39/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TKIGFLIAFLL----STMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPK 65
            |.:|.|:..|:    :...:....:.||.||.....|..|.....||.||.||||:||:......
  Fly     8 TGLGILLIGLIWLFAANADEGVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSD 72

  Fly    66 LATHENITVIIAPPTEERQRYIKEYMAEVSN----EKPSFWETMVKAIVQSSNQLEGQYEFMTHP 126
             ....|..||.|       :.|.|.||...|    :..|.|: |:....|..|.|  ....:...
  Fly    73 -KNEPNFRVIGA-------KKIHEIMAAFGNADYTQTASQWQ-MLTMTTQFLNLL--TTSILDDA 126

  Fly   127 NVKEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVI-ISWVGIPLPFMDTIVGNVNDPSYVPT 190
            .||::. |...|||||.:..:......|:........| ||..|.. ..:|.::||::..||.|
  Fly   127 AVKDLL-NSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTD-THIDELMGNISPLSYNP- 188

  Fly   191 VNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDY-KMNQFYERAFANELEFPNYHEMKRRVSL 254
              :.|::..:.|||..|.:|.|:.::|.:.:.::.. .....|.:.|....:  :..|:....:|
  Fly   189 --LLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLYAKYFPTARK--SLDEVLDSFAL 249

  Fly   255 LFYNYHSASEGPIRPTVPQSIEIGG--IQVKEQADPLPKELAKFLDKADEGAIFFSLGTNVNTNT 317
            :....|.:...| ||.:|..||:||  :|.|.:..||.|||::|::::::|.|:||:|:|:.:..
  Fly   250 MLLGQHFSLSYP-RPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKD 313

  Fly   318 FRPDTVDILYKVLSKLPQRVIWKWED--LKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGK 380
            ..|.|..:|.:..:.:||||:||:||  |..||   .|:|...|.||.|||||||.||||||.|.
  Fly   314 LPPSTRKMLMQTFASVPQRVLWKFEDDQLPEKP---DNVFISKWFPQPDILAHPNVKLFITHGGL 375

  Fly   381 GGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETI 445
            ....|:.|.|.|::.||||.||..|.:...:.|:|...||.::...||...|:|:|.||:|....
  Fly   376 LSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAA 440

  Fly   446 GKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVL---LVSLLL 507
            ...|.|:||:..||.:..|:||||||||:||.||:.......|:..:.||.:|:::   .||||:
  Fly   441 QTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLI 505

  Fly   508 IVTIKFLFRKILNVAIGYGSQRKAVANKLK 537
            :|.:....:::....|....:.:|.|:|||
  Fly   506 VVILIKCLQRVFVSLISKIRKNRAEASKLK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	159/481 (33%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	141/430 (33%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	158/476 (33%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	162/492 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445752
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850