DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	128/525 - (24%)
Similarity:	224/525 - (42%)	Gaps:	66/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GANILGVFGTHSPSHVIVHMAVMKALADR--GHNITVVTQMKPKLATHENITVIIAPPTEERQRY 86
            |||:|.||.:...||.:....:::.|.:.  .|::|:::..    |..|.:...|....|.|...
  Fly    18 GANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPH----AAQEGVDAEIPKIRELRIEG 78

  Fly    87 IKE--------YMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIYENPKIKFDLVF 143
            ::|        :.||....: |..|...:.|...:..::   ..::.|.|:::..:.: ||||:.
  Fly    79 LRENWLDMGMSFEAEEMRAQ-SVMERFTRLIYAGTTNVD---ILLSDPQVRKLLTSGE-KFDLLI 138

  Fly   144 LGLMANTYQLGIAAKLKCPVII-------SWVGIPLPFMDTIVGNVN----DPSYVPTVNVALNA 197
            :.|..:...||:|.....|.:.       ||       ::.:.||..    |||........:|.
  Fly   139 VDLFLSDALLGLAFYYGIPTVAVSPTGANSW-------LNNMFGNPQSSSLDPSNFLPFTERMNT 196

  Fly   198 GQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFY----ERAFANEL-----EFPNYHEMKRRVS 253
            .|:.::           ::|..||. |.|  |.|:    :..:.|..     |.|.|.::.:.:|
  Fly   197 RQRILN-----------SLMSTFER-LTY--NFFHLISQQSVYTNHFELLVKELPLYRDLTKNLS 247

  Fly   254 LLFYNYHSASEGPIRPTVPQSIEIGGIQVKE-QADPLPKELAKFLDKADEGAIFFSLGTNVNTNT 317
            |...|.|.....| |..:|..:|:||:.:.. ..|.|||.|..|::.|..|.|:||||.:|.|..
  Fly   248 LALINSHPGLHYP-RAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESAPSGVIYFSLGADVETAQ 311

  Fly   318 FRPDTVDILYKVLSKLPQ-RVIWKW--EDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAG 379
            ...:.:.|:..|...|.: ..:.||  |:...:.....|:...:|.||..||.||..|:||:..|
  Fly   312 LPQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCG 376

  Fly   380 KGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRET 444
            :..|.|:.....|::|:||..:|:..|:.:.:.|....:...::....|...||::..|.:|.|.
  Fly   377 QLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEK 441

  Fly   445 IGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIV 509
            :|:.......|..|.....:...:.:|...||..|:|......|.....:||. :::.|....|:
  Fly   442 LGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVL-LIIAVGFFGIL 505

  Fly   510 TIKFL 514
            ||.||
  Fly   506 TIPFL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	115/484 (24%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	109/454 (24%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	119/492 (24%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	104/439 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445765
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.850