DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	170/575 - (29%)
Similarity:	260/575 - (45%)	Gaps:	102/575 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQM---KPKLATHE 70
            ||::.:.....:...|:.||..|.....||.::..|:::.|..:||.:|.:|..   |.||.:
  Fly    10 FLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGS-- 72

  Fly    71 NITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLE----GQYEFMTHPNVKEI 131
            |...|:.|          :|         .||.. :|.:...:..||    ..:.|:...||..|
  Fly    73 NYKEIVIP----------QY---------DFWPE-IKEMTNKNTVLEMTDLPTFAFLRMVNVMGI 117

  Fly   132 Y------ENPKI-----------KFDLVFLGLMANTYQLGIAAKLKCPVI-ISWVGIPLPFMDTI 178
            :      |.|:|           |:||:......|...|.:....:.|.| ||..| ....:..:
  Fly   118 HTTDFALEQPEIQAVINEKNKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFG-NANHLSQL 181

  Fly   179 VGNVNDPSYVPTV---------------NVALNAGQKTMDFGLRFVNFFKYAIMCVF---ETVLD 225
            .|.|:..||||..               |||::|.:.       .|..|.|     :   :.||.
  Fly   182 FGVVSPWSYVPHAYMPYTDRMTLWERIGNVAMSAAED-------LVREFSY-----YPGQDAVLK 234

  Fly   226 YKMNQFYERAFANELEFPNYHEMKRRVSLLFYNYHSASEGPI---RPTVPQSIEIGGIQVKEQAD 287
            ...::..:|.       |...|::|.:|.:..|    |..|:   ||.....|.:||:.: :...
  Fly   235 KHFSKLLDRV-------PTIKELERNISAILLN----SYMPLASSRPMAYNMIPVGGLHI-QPPK 287

  Fly   288 PLPKELAKFLDKADEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKPGNAS 352
            .||:.|.||||.|..|||:||||:.|.:....|:.:.:..:|...|.|||:||:|| ::.|...:
  Fly   288 ALPEHLQKFLDGATHGAIYFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFED-ESLPNLPA 351

  Fly   353 NIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRW 417
            |:...:||||.|||||||.|:||.|.|..|..||.|:|||::.:|::.||..|......:.:...
  Fly   352 NVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALG 416

  Fly   418 LDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSP 482
            ||...:|..||...:.|::.||.||..|.|.|.::|||||.|..:.|||..||:.|:||.||.:.
  Fly   417 LDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAA 481

  Fly   483 LIHTKFVARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANKLK 537
            .:|..:.....||:.|:.|.|.||.||.:..:.|:        .|:.|:...|.|
  Fly   482 GVHLPWYQFYLLDIVGLGLAVILLPIVVLILICRR--------SSKPKSTPTKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	151/511 (30%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	134/466 (29%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	165/550 (30%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	159/524 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454748
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.840