DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt36D1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	147/540 - (27%)
Similarity:	258/540 - (47%)	Gaps:	79/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IAFLLS---TMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENI 72
            :|..||   .:.:::|...:||:|.....||......:||.||:.||:::||:..
  Fly    11 LALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHF---------- 65

  Fly    73 TVIIAPPTEERQRYIKEY----MAEVSN-------EKPSFWETMVKAIV------QSSN---QLE 117
                  |.:....:.|::    |.:::|       ||.:|:....:..:      |:.|   :.|
  Fly    66 ------PDKHPVAHYKDFPLTGMDKLTNSVDLKFFEKRTFYSHFQEFFLLYDWGKQTCNLTLRSE 124

  Fly   118 GQYEFMTHPNVKEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGNV 182
            ...:.:..|.          :||::.:........:|:|.:|:.|||.....:.:|:....:|..
  Fly   125 ALQQILRRPG----------RFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGAP 179

  Fly   183 NDPSYVPTVNVALNAGQKTMDFGLRFVNFFK-------YAIMCV--FETVLDYKMNQFYERAFAN 238
            ..||::|.:.:|.:   :.|:||.|..|:|.       |.::.|  .:.::.||...
  Fly   180 LIPSHIPALFMAQS---QHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGH-------- 233

  Fly   239 ELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEG 303
              :.|:..|:.:..|:.|.|.|.:..|| :.|.|..||:|||.: :::.|||.:|.:.||.|:||
  Fly   234 --DVPSVGELVKNTSMFFVNQHYSLSGP-KVTPPNVIELGGIHI-QKSKPLPADLQRILDNAEEG 294

  Fly   304 AIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWED--LKNKPGNASNIFFGNWLPQDDIL 366
            .|..|.|:.:..|:......|.:.:.:::|.|:||||||:  |.|:|   .|:....||||.|||
  Fly   295 VILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQP---PNMHIMKWLPQRDIL 356

  Fly   367 AHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQT 431
            .|||.|:|::|.|..|.:||.|.|||:||.|::|||..|...:.:.|.|..|:...:.|:.:.:.
  Fly   357 CHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRA 421

  Fly   432 IREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDV 496
            :::.| :..:.:.....|..:..||..|..:.|:|.|:|....||..|:...:........:|||
  Fly   422 LKKAL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDV 485

  Fly   497 YGVVLLVSLLLIVTIKFLFR 516
            |.|:.||...:|.:..:|.|
  Fly   486 YAVLALVLGSIIASWVWLLR 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	134/497 (27%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	122/451 (27%)
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	134/505 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454606
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	5.940