DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt301D1

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	157/523 - (30%)
Similarity:	266/523 - (50%)	Gaps:	55/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENIT 73
            :::.||:. :.:...|:.||.:....:|||.:........|..:||::|.|.. .|....|||:|
  Fly    10 WMLIFLIG-LLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNN-HPTKHPHENLT 72

  Fly    74 -VIIAPPTEERQRYIKE------YMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEI 131
             :||:|..:..:.:.||      ::::.:|.:  .|.|:        ..:..::.| ..|.||::
  Fly    73 EIIISPSFDIPKHFPKENIFSMQFVSDFNNLE--LWWTI--------GLMTTEHAF-KDPKVKKL 126

  Fly   132 YENPKIKFDLVFLGLMANTYQLGIAAKLKCPVI-ISWVGIPLPFMDTI---VGNVNDPSYVPTVN 192
            .|:....:|||.:....:...|....:..|||: |..:|    :.|.|   :|.:...|.:|.:
  Fly   127 IESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMG----YADNIDHAMGILTPWSLIPHL- 186

  Fly   193 VALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDY-----KMNQFYERAFANELE--FPNYHEMKR 250
              |.:....|.||.|..|    |.:.:::.|:..     ||.:..|:.|...:|  .||..:::|
  Fly   187 --LLSHTDRMTFGQRAYN----AYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLER 245

  Fly   251 RVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKADEGAIFFSLGTNVNT 315
            .:||:..|.|.:.:.| ||::|..|::||..: ::...||.:|..|||.|..|.|:||:|:.|.:
  Fly   246 NISLVLINAHRSIDLP-RPSMPGLIDVGGAHI-QKPKQLPTDLQNFLDNATYGVIYFSMGSYVKS 308

  Fly   316 NTFRPDTVDILYKVLSKLPQRVIWKWED--LKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHA 378
            .....:...::.|...:|.|:||||:|:  :.:.|   ||:....|:||:|||||||.||||||.
  Fly   309 TDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLP---SNVMIKKWMPQNDILAHPNVKLFITHG 370

  Fly   379 GKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRE 443
            |..|..|..|.||||:.:|::|||..|.....:.|:.|.|....:|..:|.:.|..::.:|.|:.
  Fly   371 GIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKR 435

  Fly   444 TIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNN---LDVYGVVLLVSL 505
            :..:.|..:||.|:.......:|.||::||:||.||:|   |..|:..:.   |||.|.:||.:.
  Fly   436 SALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKS---HGAFIPLHQYLLLDVLGCLLLGAF 497

  Fly   506 LLI 508
            |.|
  Fly   498 LAI 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	142/485 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	130/440 (30%)
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	149/502 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	143/476 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.910