DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	152/553 - (27%)
Similarity:	257/553 - (46%)	Gaps:	108/553 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHVIVHMAVMKALADRGHNITVVTQMKPKLATHENITVIIAP-----------PTEERQRYIKEY 90
            ||.:....::..|..|||.:||   :||      :...::.|           ||...:..:::|
  Rat    34 SHWMNIKTILDELVQRGHEVTV---LKP------SAYYVLDPKKSPDLKFETFPTSVSKDELEKY 89

  Fly    91 -----------------------MAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVKEIY 132
                                   :..:.:|...::.::.|..| |:.||..:.:
  Rat    90 FIKLVDAWTYELQRDTCLSFSPLLQNMMDEFSDYYLSVCKDAV-SNKQLMAKLQ----------- 142

  Fly   133 ENPKIKFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGN-VNDPSYVPTVNVALN 196
               :.|||::....:|...:| ||..|..|.:.|....|...::...|. :..|||||.:...|
  Rat   143 ---ESKFDVLLSDPVAACGEL-IAEVLHIPFLYSLRASPGHKIEKSSGRFILPPSYVPVILSGL- 202

  Fly   197 AGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFPNYHEMKRRVSLLFYNYHS 261
            .||.|      |::..|..|..::   .|:..:.|..:.:.     |.|.|:..|.:.|......
  Rat   203 GGQMT------FIDRVKNMICMLY---FDFWFHMFNAKNWD-----PFYTEILGRPTTLAETMGK 253

  Fly   262 ASEGPIR---------PTVPQSIEIGGIQVKEQADPLPKELAKFLDKADE-GAIFFSLGTNVNTN 316
            |....||         ||:|....|||:|.| .|.||||::..|:..:.| |.:.||||:.|::.
  Rat   254 AEMWLIRSYWDLEFPHPTLPNVDYIGGLQCK-PAKPLPKDIEDFVQSSGEHGVVVFSLGSMVSSM 317

  Fly   317 TFRPDTVDILYKVLSKLPQRVIWKWE-DLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGK 380
            |  .:..:.:...|:::||:|:||:: .:....|..:.::  .||||:|:|.||.||.|:||.|.
  Rat   318 T--EEKANAVAWALAQIPQKVLWKFDGKIPATLGPNTRVY--KWLPQNDLLGHPKTKAFVTHGGA 378

  Fly   381 GGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETI 445
            .||.||.|||:||:.:|:||:|..|...|...|....|:|.||::.:|...::||:.||.|::..
  Rat   379 NGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEVINNPFYKKNA 443

  Fly   446 GKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHT-KFVARNNLDVYGVVL----LVSL 505
            ...||::.|:|:......|:|.|||:||:.|.||: ||.|. .:...::|||.|.:|    :::.
  Rat   444 MWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLR-PLGHNLPWYQYHSLDVIGFLLACLAVIAA 507

  Fly   506 LLIVTIKFLFRKILNVAIGYGSQRKAVANKLKN 538
            |.:....|::|       .:..::|    |:||
  Rat   508 LAVKCFLFIYR-------FFAKKQK----KMKN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	134/483 (28%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	123/456 (27%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	149/549 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810