DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_659094.1	Gene:	Ugt3a2 / 223337	MGIID:	2145969	Length:	523	Species:	Mus musculus

Alignment Length:	559	Identity:	149/559 - (26%)
Similarity:	247/559 - (44%)	Gaps:	81/559 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITV-------VTQMKPKL 66
            ||...||.       .|.||.: .|.|.||.||...|.:.|.:.|||:|.       :...:.:.
Mouse    14 FLEVILLE-------AAKILTI-STLSASHYIVISRVSQVLHEGGHNVTKLLYESANIPDFRKEK 70

  Fly    67 ATHENITVIIAPPTEERQRY--IKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTHPNVK 129
            .:::.|.  ..||.::.:::  ::..:.|......|...|::| |.|....|..|  .::..::.
Mouse    71 PSYQVIN--WRPPEDQEKKFADLRHRLTEEITYGRSKHHTLLK-IHQYFGDLCSQ--LLSRKDIM 130

  Fly   130 EIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTIVGNVNDP-SYVPTVNV 193
            :..:|.  .||||.|..| :...|.|..||. ...:|::.....:||  .|..:.| ||.|....
Mouse   131 DFLKNE--NFDLVLLDSM-DLCSLLIVEKLG-KRFVSFLPFQFSYMD--FGLPSAPLSYAPVYGS 189

  Fly   194 ALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQ-----FYERAFAN---ELEFPNYHEMKR 250
            .|.   ..|||..|..||..:         ||:.|.|     .|:.....   |...|...::..
Mouse   190 GLT---DQMDFWGRVKNFLMF---------LDFSMKQREILSQYDSTIQEHFVEGSQPVLSDLLL 242

  Fly   251 RVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDK-ADEGAIFFSLGTNVN 314
            :..|.|.|...|.:. .||..|.::.:||: :.:...|:|::|..|:.: .|.|.:..:||:.|:
Mouse   243 KAELWFVNSDFALDF-ARPLFPNTVYVGGL-LDKPVQPIPQDLENFISQFGDSGFVLVALGSIVS 305

  Fly   315 TNTFRPDTVDILYKVLSKLPQRVIW-----KW-EDLKNKPGNASNIFFGNWLPQDDILAHPNTKL 373
            ....: :.:..:....:.|||.|:|     .| :|:...|    |:...:||||.|:||||:.:|
Mouse   306 MIQSK-EIIKEMNSAFAHLPQGVLWTCKTSHWPKDVSLAP----NVKIMDWLPQTDLLAHPSIRL 365

  Fly   374 FITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREVLGN 438
            |:||.|...|.||.:||||||.:|.|.||..|...:.....|..:.:.|:.......|:::::.:
Mouse   366 FVTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAESFALTMKKIIED 430

  Fly   439 PAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHL-----QSPLIHTKFVARNNLDVYG 498
            ..|:........:....|||..|.::.|.:::|:..||.||     |.|. |.:::    |||:
Mouse   431 KRYKSAAMASKIIRHSHPLTPAQRLLGWIDHILQTGGAAHLKPYAFQQPW-HEQYM----LDVF- 489

  Fly   499 VVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANKLK 537
               |..|.|::...:|..|:|.....|.|    :|.|:|
Mouse   490 ---LFLLGLMLGTLWLSVKVLVAVTRYLS----IATKVK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	128/490 (26%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	117/445 (26%)
Ugt3a2	NP_659094.1	UDPGT	23..488	CDD:278624	132/500 (26%)
Ugt3a2	NP_659094.1	egt	<235..488	CDD:223071	74/264 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840