DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt-54

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	136/563 - (24%)
Similarity:	229/563 - (40%)	Gaps:	110/563 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TKIGFLIAFLLSTMTQSSGGANILGVF---GTHSPSHVIVHMAVMKALADRGHNI-TVVTQMKPK 65
            |.:||||.         .|.||.|.:.   ...:.||:..|...:|.|.||||.: .|:.|:
Worm     3 TLLGFLIL---------PGFANCLNILFYVSVIAQSHIPFHNTAIKVLLDRGHTVDLVIAQL--- 55

  Fly    66 LATHENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQY--------EF 122
                 |..|.:..|....:.|...|      |.|:|:.       :::..|...:        ||
Worm    56 -----NEMVKLKFPNGVGKNYTFGY------EDPNFYR-------KNAGHLSDIFVEKPIPMAEF 102

  Fly   123 MTHPNV-----KEIYENPKIKFDLVFLGLMANTYQLGIAAKL-KCPVIISWVG--------IPLP 173
            :|..::     :.:.::|.:   |.:  :....|.:|:::.. .|..|:...|        :|.|
Worm   103 LTFDDMTFNLCETVVKDPNL---LNY--IKQGNYDIGLSSDYDPCANILMHAGGVPSKASMVPTP 162

  Fly   174 FMDTIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFK--YAIMCVFETVLDYKMNQFYERAF 236
            .....:.:...||........|........|. |..:..:  |.|..|...::: |.|......|
Worm   163 LFQPQIVSAGLPSPASVYGTVLYPKGDDSFFN-RLFHLIRHTYNIYFVAPRLME-KYNNLLLETF 225

  Fly   237 ANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKAD 301
            ..  .||:..|::|.|.::..|.:...|.| ||...:...|||:. |::|.||.||....|..::
Worm   226 GP--TFPSAEEIERNVDIILVNSNEIIEKP-RPVSHKIKYIGGMG-KKKAQPLNKEFNDILATSN 286

  Fly   302 EGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRV----------------IWKWEDLKNKP-- 348
            :|.:.||.||.|.|               ||:|..:                :||:::|.:..
Worm   287 KGVVLFSFGTQVAT---------------SKVPIEIRKNFVTAFKHFPDFSFLWKYDNLTDDAEL 336

  Fly   349 -GNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKS 412
             .::|||....||||.|:|.....|.||:|.|.....|....|:|::|:|:|.|||.||......
Worm   337 FADSSNIHRVEWLPQTDLLGDNRVKAFISHMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSR 401

  Fly   413 GFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGAL 477
            ..|..::...:|...|...::::|.||.|.|.....|.:..::|..:.:..:.|.||..::.| |
Worm   402 DIGVIVERHQLTVENLVNALQKLLYNPKYGENAKMISKMMNEKPEQSERLFVDWVEYAAKNPG-L 465

  Fly   478 H--LQSPLIHTKFVARNNLDVYGVVL--LVSLLLIV--TIKFL 514
            |  :..|..........::||..:|:  |.|.|:|:  |:.|:
Worm   466 HKIMNLPGAELTPFWYYSVDVILIVVLSLTSSLIIIWKTLSFI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	122/514 (24%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	110/467 (24%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	123/519 (24%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	82/299 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910