DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt-41

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_504818.2	Gene:	ugt-41 / 184295	WormBaseID:	WBGene00017336	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	135/545 - (24%)
Similarity:	229/545 - (42%)	Gaps:	56/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IGFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALAD----RGHNITV---VTQMKP 64
            :..||..||.....::.|.|.|.|    ||:....|...|..|||    .|||:||   :...|.
Worm     1 MNLLIILLLVLSISNTSGFNYLVV----SPAFGHSHSTFMGKLADSLTEAGHNVTVLSIIISSKF 61

  Fly    65 KLATHENIT---VIIAPPTEERQRYIKEYMAEVSNEKPSFW-------ETMVKAIVQSSNQLEGQ 119
            :..::...|   |::...||:.|  :.|.|.  :::...:|       ||:...::......:|.
Worm    62 RNISYTKSTKDIVVVETTTEQDQ--LTENME--NDDFARYWTQEGTMLETIPSYLMFLKMAEDGY 122

  Fly   120 YEFMTH--PNVKEIYENPKIKFDLVFLGLMANTYQLGIAAK--LKCPVIISWVGIPLPF-MDTIV 179
            ..|..|  |.: :..:|.:.::|.||   ..:.:.:|.|.:  |:.||.:....|...: ...::
Worm   123 KTFRDHALPQM-DYLKNNRPQYDAVF---FESFFFMGKAIQEYLEIPVFLPVTSITHDYRFAELI 183

  Fly   180 GNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELEFPN 244
            |....|||:.  ....|.| ..|:|..|..|...|.:..:.....::|..|...:....|.|
Worm   184 GEPVSPSYLS--GYFTNFG-NIMNFQERLTNTISYYLGQILIAFPNWKTLQDPSKDLLVESE--- 242

  Fly   245 YHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQV---KEQADPLPKELAKFLDKADEGAIF 306
            ||    |...:|.|.:...:.| ||.:.::||||||.|   |.:::.:.::....|.|.... :.
Worm   243 YH----RAPYVFINSNPYIDFP-RPLLSKTIEIGGITVDVKKLKSEKVDEKWDNILKKRPHN-VL 301

  Fly   307 FSLGTNVNTNTFRPDTV-DILYKVLSKLPQ-RVIWKWEDLKNKPGN-ASNIFFGNWLPQDDILAH 368
            .|.| ::..:.:.||.. :.:.||:..... ..|||:|..:....| |.||.|..|:||..:||.
Worm   302 ISFG-SMFKSIYMPDFYKENMVKVMKSFKNVSFIWKYESEETSFANGAENIIFSKWVPQTALLAD 365

  Fly   369 PNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHE-LEQTI 432
            .....|.||.|.|.|.|..|.|.|.:..|:|.||..|::::|:......:....:..:. |...:
Worm   366 SRLSAFFTHGGLGSVNELSYLGKPALLCPLFADQIRNSKMLTRHNGSIEISKFNLENYNTLRSAL 430

  Fly   433 REVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTK-FVARNNLDV 496
            ..:|...:|.|...|.:.....:|...::..:...|:..|. |....|...:.|. |.|...|||
Worm   431 HSILFAESYSENAEKLAKKLEYQPTKPKELFVRHAEFAARF-GEQPAQDSNLRTMGFAAYYLLDV 494

  Fly   497 YGVVLLVSLLLIVTIKFLFRKILNV 521
            ...:....||:|..:..:.|:|:.:
Worm   495 IAFLTSFVLLVIFVVFIMIRQIVKL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	122/496 (25%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	112/449 (25%)
ugt-41	NP_504818.2	UDPGT	22..510	CDD:278624	127/513 (25%)
ugt-41	NP_504818.2	Glycosyltransferase_GTB_type	26..512	CDD:299143	124/507 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910