DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt-15

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_506211.1	Gene:	ugt-15 / 183462	WormBaseID:	WBGene00008097	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	140/560 - (25%)
Similarity:	230/560 - (41%)	Gaps:	86/560 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KIGFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNIT----VVTQMKPKL 66
            |:.||:..||..:..|.........||.   ||......:...|.|.||::|    |..:.|..|
Worm     2 KLPFLLTLLLLELVCSYKVLVFNPAFGA---SHSNFLGKISDILIDAGHDVTMLIPVCMESKKDL 63

  Fly    67 ATHENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWE---------TMVKAI-VQSSNQLEGQYE 121
            ...:.:..||....|.|.:.::|........|...|:         :|:|.. :.|..|.|..::
Worm    64 VGSKKVKKIIRIDQEPRSKLMQEEAKTEEMIKKQIWKLDADITIFFSMIKNFSIASGYQCENIFK 128

  Fly   122 FMTHPNVKEIYENPKIKFDLVFLGLMANTYQLGIAAKLKCPVIISWVGI-------PLPFMDTIV 179
               ...:.|...|.  .||   ||:..:.:..|.      |::.| :|:       .:.::|.:.
Worm   129 ---QTAILEQLRNE--HFD---LGITESLFICGF------PLLDS-IGVKTIINADSVLYLDVVK 178

  Fly   180 GNVNDP---SYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELE 241
            ..:.:|   ||.|.| .|.|..:  |.|..|..|.|..|....|...           .|..|||
Worm   179 HALGEPASTSYYPGV-YAKNIDR--MSFRERVRNLFGMAFSWYFSWT-----------RFQGELE 229

  Fly   242 F--PNYHEMK------RRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQV---KEQADPLPKELAK 295
            .  |.|::..      ...:..|.|.:...:.| .||:|:::.|||:||   |.....|.||...
Worm   230 AIKPYYNKSLTWEDHINGAAYYFINSNQYLDYP-SPTLPKTVFIGGMQVNTNKHGKVKLEKEWDD 293

  Fly   296 FLDKADEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRV-IWKWEDLKNKPGNA------SN 353
            .|:...:. :..|.|:|..:.....:..:...||.:.:|:.. |||:|.     .||      ||
Worm   294 LLNLRKQN-VLVSFGSNAFSCDMPDEFKESFLKVFASMPETTFIWKYEQ-----ENATLADQLSN 352

  Fly   354 IFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWL 418
            :....|:||:||||.....||:||.|.|...|..|.|.|.|.:|:..||..||.::|:.|....|
Worm   353 VKLTTWMPQNDILADERLTLFVTHGGLGSSMELAYQGKPAVVIPLMADQPRNALMLTRHGGALQL 417

  Fly   419 DILTMTEHE-LEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSP 482
            |...:...| :.:.|:.|:.||:|::...|.:.:...:|...:..|:...::.::|.....|.|.
Worm   418 DKTFLNNSEKIREAIQTVMENPSYKKNAEKLANILSSQPHQPKDVVLKHCDFAVKHGDLKTLNSE 482

  Fly   483 LIHTKFVARNNLDV---YGVVLLVSL-LLIVTIKFLFRKI 518
            ..|.......::|:   .|:.|:..: .:|.||.|:|:|:
Worm   483 GRHLNVFQYYSIDIALAAGLFLVTIISFIIFTIIFVFKKV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	127/510 (25%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	118/463 (25%)
ugt-15	NP_506211.1	UDPGT	19..506	CDD:278624	128/525 (24%)
ugt-15	NP_506211.1	Glycosyltransferase_GTB_type	<252..493	CDD:299143	70/247 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910