DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and ugt-21

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001293944.1	Gene:	ugt-21 / 183141	WormBaseID:	WBGene00007885	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	129/546 - (23%)
Similarity:	237/546 - (43%)	Gaps:	72/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FLLSTMTQSSGGANIL---GVFGTHSPSHVIVHMAVMKALADRGHNITVV-----------TQMK 63
            |:|:::........||   .:|| |  |||.|..|....|.|.|:|:||:           |.:|
Worm     8 FILTSIISCVSSYKILLYSNLFG-H--SHVKVLAAAADILTDAGNNVTVLMPVFDNNLRNKTSLK 69

  Fly    64 PKLATHENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETMVKAIVQSSNQLEGQ-YEFMTHPN 127
               :|...|.|...|..||....:::::|....|......||:||..........| .:.::.|.
Worm    70 ---STKNTIFVEAGPNVEELMSDMRQFLANAWKEDTGNPITMMKAAQDMGTAFAEQCTKVISEPG 131

  Fly   128 VKEIYENPKIKFDLVFLGLMANTYQLGI-------------AAKLKCPVIISWVGIPLPFMDTIV 179
            :.|     |:|         |..|.|.|             |..::..|.|    :.....|.:.
Worm   132 LLE-----KLK---------AENYDLAITEPFDTCGYALFEAINIRAHVAI----LTANRFDHVT 178

  Fly   180 GNVNDP---SYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFANELE 241
            ..:..|   ||||  ......|.: |..|.|..|:|::.:...|.:::.   ::.:|.|.:....
Worm   179 DVIGQPIASSYVP--GTQSETGDR-MTMGERLGNYFQFLVGSYFFSLIG---DRDFEAAKSVVPI 237

  Fly   242 FPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQAD--PLPKELAKFLDKADEGA 304
            ..::..:....|.:..|.....:.| .||..:.:.|||:.||.:..  .|.::.:|.|. ..:..
Worm   238 TRSWRAILPEASFILTNQIPLLDFP-APTFDKIVPIGGLSVKTEKKNLKLDEKWSKILG-IRKNN 300

  Fly   305 IFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRV-IWKWEDLKNKPGN-ASNIFFGNWLPQDDILA 367
            :|.|.|:|..:.....:..:.|..|...:|... |||:|:..:...| ..|:..|:||||:::||
Worm   301 VFISFGSNAKSVDMPDEFKNSLADVFKSMPDTTFIWKYENTSDPIVNHLDNVHLGDWLPQNELLA 365

  Fly   368 HPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTE-HELEQT 431
            .|...:|:||.|.|.|.|....|.|.|.:|:|.||..||:::.:.|....::...:.: |.:::|
Worm   366 DPRLSVFVTHGGLGSVTELAMMGTPAVMIPLFADQGRNAQMLKRHGGAVVIEKNNLADTHFMKET 430

  Fly   432 IREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDV 496
            :.:|:.:|.|.|...:.:.:..::|...::::|.:.|:..|......|.:...|..::....||:
Worm   431 LEKVIKDPKYLENSKRLAEMLTNQPTNPKETLIKYVEFAARFGKLPSLDNYGRHQSYIEYFFLDI 495

  Fly   497 YGVVLLVSLLLI----VTIKFLFRKI 518
            ..::.::||..:    :.::.:.|||
Worm   496 IAILAVISLFSLYISYIILRAVIRKI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	120/497 (24%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	114/456 (25%)
ugt-21	NP_001293944.1	UDPGT	32..526	CDD:278624	122/519 (24%)
ugt-21	NP_001293944.1	egt	<263..504	CDD:223071	62/241 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910