DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt-6

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001369960.1	Gene:	ugt-6 / 179755	WormBaseID:	WBGene00013904	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	128/576 - (22%)
Similarity:	236/576 - (40%)	Gaps:	122/576 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIAFL-LSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADR----GHNIT-----VVTQMKP 64
            ::.|| :||:..::.....|.:    ||.:...||..|..||:.    |:::|     ||.:.
Worm     4 IVLFLFISTLFGNAYSYKFLVI----SPVYGFSHMKYMAELANHLARAGNDVTYFQPFVVDEY-- 62

  Fly    65 KLATHENITVIIAPPTEERQRYIK---EYMAEVSNE------------KPSFWETMVKAIVQSSN 114
                |::..:        :::.||   .|..|:..:            ..|::::...|.:..|.
Worm    63 ----HDHTLI--------KEKSIKIWNYYHDELGRQHIPSQGCMRDAWHSSWYQSDAGAAILLSK 115

  Fly   115 QLEGQYEFMTHPNVKEIYENPKIKFDL------VFLGLMANTYQLGIAAKLKCPVIIS-WVGIPL 172
            .|...:|.|    .::::|:.::.:||      |.|....:...|.:|:.|:.|.||| :.|..|
Worm   116 YLFPAFEHM----CRKMFEDTELHYDLKSRQFDVVLSEAFDFCGLYLASYLEMPSIISTFTGNRL 176

  Fly   173 PFMDTIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAFA 237
            ..:..::|..:...|:|.         .|..:|..             .|:.| ::|..:.:.::
Worm   177 NALAPVLGEPSFLHYLPA---------PTSQYGHE-------------STIFD-RLNDVWHKIWS 218

  Fly   238 NELEFPNYHEMK-RRVSLLF-------------YNYHSASEGP----IRPTVPQSIEIGGIQVKE 284
            : ..|....||: ::||.|.             ..||.::..|    :.||:|:.:.||||.|..
Worm   219 S-YGFAQLFEMQYQQVSKLTNGKVKHWKDIIHDVTYHFSNSNPYLDFVIPTIPKVVPIGGITVDH 282

  Fly   285 ---QADPLPKELAKFLDKADEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQ-RVIWKW---- 341
               ..:....||.:.:..|.:..:|.|.|:.|.:.....:....:.||.|..|. ..:||:
Worm   283 DYWSTNGNHSELLEHVLNARKHNVFISFGSMVRSVDMPKEFKKSMMKVFSDHPNITFLWKYELPN 347

  Fly   342 --EDLKNKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQG 404
              |.|:..|   :|:....|..|..:|:.....||:||.|.|...|......|.:.:|:|.||.|
Worm   348 DQEFLRILP---TNVHVAKWFSQSALLSDQRVNLFVTHGGLGSTMELARAAKPAIVIPLFADQPG 409

  Fly   405 NAEIMTKSG----FGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIY 465
            ||:::.:.|    |.: |||  ....:|...|:::|....|::...:.:...|.:|:|....::.
Worm   410 NAKMIERHGSVEIFSK-LDI--PNSKKLSSLIQKMLNTKYYQQNANRLADTLRFQPITPTDLMVK 471

  Fly   466 WTEYVLRHQGALHLQSPLIHTK---FVARNNLDVYGVVLLVSLLLIVTIKFLFRKI 518
            ..|...|. |.:....|  |.|   |....|:|:..:|.|:..||...:..:|.|:
Worm   472 HAENAARF-GKMPNLVP--HAKDMGFFEYYNIDIIFIVFLLVWLLFSVVAHVFSKL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	115/528 (22%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	106/483 (22%)
ugt-6	NP_001369960.1	GT1_Gtf-like	20..456	CDD:340817	106/487 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910