DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt-51

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_504388.2	Gene:	ugt-51 / 178905	WormBaseID:	WBGene00015369	Length:	524	Species:	Caenorhabditis elegans

Alignment Length:	559	Identity:	131/559 - (23%)
Similarity:	233/559 - (41%)	Gaps:	86/559 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KIGFLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLAT-H 69
            :|.|....:|:.:......|||:........||:....:::.:|.::||.:.:|......||. :
Worm     3 QIHFCALTILAVLPLFLNAANIVFFINAIGKSHLDFGDSLIDSLKEKGHTVDLVIARINDLAKGN 67

  Fly    70 ENITVIIAPPTEERQRYIKEYMAEVSNEKPSFWETM----------------VKAIVQSSNQL-- 116
            ||         .:..|:   |.....|  .|.|..:                .:......|||
Worm    68 EN---------SKADRF---YTLGFKN--GSSWHKLNHLTSPFENNPFPIDGFRQYTLIGNQLCE 118

  Fly   117 -----EGQYEFMTHPNVKEIYENPKIK-FDLVFLGLMANTYQLGIAAKLKCPVIISWVGIPLPFM 175
                 |..::|::    ::.|:...:. ||...:|::   .:.|:::      |.::..:||..:
Worm   119 IALHDEKLHQFLS----EKSYDVGVVSVFDYCGIGIL---NKAGVSS------ITTFNAVPLMSI 170

  Fly   176 DTI-VGNVNDPSYVP----TVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERA 235
            .|: :|..|..|.|.    |.::|..:|:.........:||.:...:...:.:|..|:   |..:
Worm   171 QTVTIGLPNIASQVVPLFYTFDLATLSGKLWNLITWAHINFHQIPTLRKEQELLFQKV---YGPS 232

  Fly   236 FANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIE-IGGIQVKEQADPLPKELAKFLDK 299
            |       :.:|:..:|.|.|.|.:...|.|:  .:...|: ||||.:| ...|:...|...|.|
Worm   233 F-------SINEVIDKVDLSFVNSNEIMETPM--LINHRIQYIGGINLK-TPKPVDHHLDNLLSK 287

  Fly   300 ADEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQ-RVIWKWEDLKNKPG------NASNIFFG 357
            :..|.|.||.||.:....:....|....||..|.|: ..:||:   ..:||      :|.|:...
Worm   288 SSNGTIIFSFGTQIPGAVYPRYAVRNFVKVFKKYPEYTFLWKY---NVQPGEEKLFEDAENVILL 349

  Fly   358 NWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILT 422
            :||||.|:|..|....||:|.|.....||.|.|.|::|:|:|.||..||......|....|:...
Worm   350 DWLPQTDLLYDPRVIGFISHVGLNSFNEASYAGKPIIAIPLFADQPHNARNGVARGTTYLLNKSK 414

  Fly   423 MTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTK 487
            ::|..:|..:|.:|.:.:|.|:..|...:..::|...:...:.|.||...:.| ||....|...|
Worm   415 LSEESIENGLRAILFDKSYTESARKLQKMLVEKPTKPKDRFVEWMEYAAVNPG-LHKIFALPGAK 478

  Fly   488 FVARNNLDVYGVVLLVSLLL-IVTIKFLFRKILNVAIGY 525
            .   .|::.|.|..:|.:.. .||..::|.|:...::.:
Worm   479 M---GNIEYYCVDTIVFIAFSCVTFTYIFFKMAKFSLSF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	118/505 (23%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	108/458 (24%)
ugt-51	NP_504388.2	UDPGT	43..505	CDD:278624	121/508 (24%)
ugt-51	NP_504388.2	egt	<217..496	CDD:223071	83/298 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910