DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37E1 and ugt-24

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	135/524 - (25%)
Similarity:	233/524 - (44%)	Gaps:	54/524 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHVIVHMAVMKALADRGHNITVV------TQMKPKLATHENITVIIAPPTEERQRYIKEYMAEVS 95
            ||:.|...|...|.|.|||:|:.      :|:.......:|  ||...|.||    :.|.|:::.
Worm    32 SHIKVLNTVADTLTDAGHNVTIFRPIIESSQLDKSSVKTKN--VIYIEPDEE----VVEKMSKID 90

  Fly    96 NEKPSFW---ETMVKAIVQSSNQLEGQYEFMTHPNVKEIYENPKI-------KFDLVFLGLMAN- 149
            ....|.|   .|...|::..||.|.|.:    ....|::....||       .|||.....:..
Worm    91 QFSGSLWTFDSTHPSAMIAKSNALVGFF----GTQCKKVMRQQKILDQLRDENFDLAITEPVDGC 151

  Fly   150 TYQLGIAAKLKCPV-IISWVGIPLPFMDTIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFK 213
            .|.:....|::..| ::|.|  ....:..|:|....|||||......|......:..|.|:.|
Worm   152 AYAIFEYLKIRDHVTVLSCV--RFDHVSDILGQPIAPSYVPGTQSFFNDRMTMKERLLNFIQF-- 212

  Fly   214 YAIMCVFETVLDYKMNQFYERAFANELEFP-NYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEI 277
            |.....|..:||    |.||.| .:.|... ::.|:....|.:|.|:....:.| .||..:.|.|
Worm   213 YYGRFTFANILD----QEYEMA-KDILGIQRSWREVLPEASFIFSNHIPVLDFP-SPTFDKIIPI 271

  Fly   278 GGIQVK--EQADPLPKELAKFLDKADEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRV-IW 339
            ||..||  |::..:.|:....|:...:. :..|.|:|..:.....:....|.:|.|.:|... ||
Worm   272 GGFTVKTNEKSLKIDKKWDAILNIRKKN-VLISFGSNAKSKDMPEEYKKTLLRVFSSMPDTTFIW 335

  Fly   340 KWEDLK-NKPGNASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQ 403
            |:||.. |...|..|:|..:||||:::||.....:|:||.|...|.|....|.|.:.:|||.||.
Worm   336 KYEDPNVNIAKNLDNVFISSWLPQNELLADSRVTVFVTHGGLASVMELALMGKPAIMIPIFADQG 400

  Fly   404 GNAEIMTKSGFGRWLDILTMTEHEL-EQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWT 467
            .||:::.:.|....|....::..:| ..|:.:||..|:|:....|.:.:..::|..|::.::...
Worm   401 RNAQMLKRHGGAAVLQKTDLSNFDLVRDTLNDVLTKPSYKLNAKKLAEMLNNQPTNAKEVLVKHV 465

  Fly   468 EYVLRHQGALHLQSPLIHTKFVARNNLDVYGV-VLLVSLLLIVTIKFLFRKILNVAIGYGSQRKA 531
            |:..|. |.|    |::......:|.::.|.: :|.:.|.:::::.::|.::|...:   |:.::
Worm   466 EFAARF-GKL----PMLDNYGRHQNIVEYYFIDILTIILSVLISVFYIFVRLLRFML---SRNRS 522

  Fly   532 VANK 535
            ..:|
Worm   523 TKDK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	124/461 (27%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	119/434 (27%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	133/515 (26%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	71/259 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910