DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	153/520 - (29%)
Similarity:	246/520 - (47%)	Gaps:	57/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHVIVHMAVMKALADRGHNITVVT-QMKPKLATHENITV---IIAPPTEERQRYIKEYMAEVSNE 97
            ||......|::.|..:||.:.||. ::..:|....|.||   .::...|:..|..|.::
  Rat    36 SHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPLNFTVKTYSVSHTQEDLNREFKFFI------ 94

  Fly    98 KPSFWETMVKAIVQS--SNQLEGQYEFMTHPNVKEIYENPKI-------KFDLVFLGLMANTYQL 153
             .|.|:|..:..|..  ::..:|.:|.: ..:.:.::::.|:       .||.|||... :...|
  Rat    95 -DSQWKTQQEGGVLPLLTSPAQGFFELL-FSHCRSLFKDKKLVEYLKQSSFDAVFLDPF-DVCGL 156

  Fly   154 GIAAKLKCPVIISWVGIPLPFMDTIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYA--- 215
            .:|.....|.::...||...:::......:.|||||...:.|.   .||.|..|..|...|.
  Rat   157 TVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPPSYVPRGILKLT---DTMTFKERVWNLLSYMGEH 218

  Fly   216 IMC--VFETVLDYKMNQFYERAFANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIG 278
            ..|  .|:|..|.............:|..|        ||:.........|.| ||.:|..|.||
  Rat   219 AFCPSFFKTATDIASEVLQTPVTMTDLFSP--------VSVWLLRTDFTLELP-RPVMPNVIHIG 274

  Fly   279 GIQVKEQADPLPKELAKFLDKADE-GAIFFSLGTNVNTNTFRPDTVDI-LYKVLSKLPQRVIWKW 341
            ||.. .|..||.||...:::.:.| |.:.||||:.|:.   .|:...: :.:.|.::||.|:|::
  Rat   275 GINC-HQRKPLSKEFEAYVNASGEHGIVVFSLGSMVSE---IPEKKAMEIAEALGRIPQTVLWRY 335

  Fly   342 EDLKNKPGN-ASNIFFGNWLPQDDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGN 405
            ..  .:|.| |.|.....||||:|:|.||..:.||||:|..|:.|...:|||||.:|:||||..|
  Rat   336 TG--TRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDN 398

  Fly   406 AEIMTKSGFGRWLDILTMTEHELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYV 470
            |:.|...|.|..|::|.||..:||..::.|:.|.:|:|.|.:.|:|::|||:......::|.|||
  Rat   399 AKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYV 463

  Fly   471 LRHQGALHLQSPLIHTKFVARNNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKAVANK 535
            :||:||.||:.......:...::|||.|.:|.:    ::|:.|:..|    :..||. ||....|
  Rat   464 MRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAI----VLTVVFIVYK----SCAYGC-RKCFGGK 519

Fly 536 535
Rat 520 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	136/458 (30%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	125/431 (29%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	153/520 (29%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	93/250 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910