Protein Alignment Ugt37E1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_652628.2
• Gene: Ugt37E1 / 53512
• FlyBaseID: FBgn0040261
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 143/540 - (26%)
• Similarity: 242/540 - (44%)
• Gaps: 130/540 - (24%)

  Fly    37 SHVIVHMAVMKALADRGHNITVVTQMKPKLATHEN----ITVIIAPPTEERQRY--IKEYMAEV- 94
            ||.:....:::.|..|.||:||:.. ...|..:.|    :...:.|.:.::...  :.|:|..:
Human   241 SHWLNIKIILEELIQRNHNVTVLAS-SATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIMLW 304

  Fly    95 SNEKP------SFWETMVKAI---VQSSNQL-EGQYEFMTHPNVKEIYENPKIKFDLVFLGLMAN 149
            .:.:|      :|::.:.|.:   .|.:.|| :|            :.:|||         |||.
Human   305 IDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDG------------VLKNPK---------LMAR 348

  Fly   150 TYQLGIAAKLKCPVIISW----VGIPLPFMDTI-----------VGNVNDP-SYVPTVNVALNAG 198
            ..:.|....:..||.|..    :.:.:|||.|:           .|.:..| ||||   .||:..
Human   349 LQKGGFDVLVADPVTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVP---AALSEL 410

  Fly   199 QKTMDFGLRFVNFFKYAIMCVFETVLDY-------KMNQFYERAFAN------------------ 238
            ...|.||.|..|...|::.       ||       :.|.:|.:....
Human   411 TDQMTFGERIKNTISYSLQ-------DYIFQSYWGEWNSYYSKILGRPTTLCETMGKAEIWLIRT 468

  Fly   239 --ELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKAD 301
              :.|||                        ||.:|....:||:..| .|.|||||:.:|:..:.
Human   469 YWDFEFP------------------------RPYLPNFEFVGGLHCK-PAKPLPKEMEEFIQSSG 508

  Fly   302 E-GAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKP---GNASNIFFGNWLPQ 362
            : |.:.||||:.|...|  .:..:::...|:::||:|:|:::.  .||   ||.:.:|  :|:||
Human   509 KNGVVVFSLGSMVKNLT--EEKANLIASALAQIPQKVLWRYKG--KKPATLGNNTQLF--DWIPQ 567

  Fly   363 DDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHE 427
            :|:|.||.||.||||.|..|:.||.|||||||.:|:|.||..|...|...|....:::.|||..:
Human   568 NDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVD 632

  Fly   428 LEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARN 492
            |...:|.|:..|:|:|...:.|.::.|:|:......::|.|:|:||:||.||:.......:...:
Human   633 LLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYH 697

  Fly   493 NLDVYGVVLL---VSLLLIV 509
            :|||.|.:|:   .::.|::
Human   698 SLDVIGFLLVCVTTAIFLVI 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	GT1_Gtf-like	25..466	CDD:340817	128/492 (26%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	143/540 (26%)