DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37E1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	560	Identity:	163/560 - (29%)
Similarity:	266/560 - (47%)	Gaps:	76/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIAFLLSTMTQSSGG--ANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQ-----MKPKLA 67
            |:...||.:|..|.|  .||| |:.|.. ||.|....|:..|.|||||:||:..     ||.|.:
Zfish     3 LVVCFLSLLTVFSAGQCGNIL-VWYTEG-SHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKES 65

  Fly    68 ---THENITVIIAPPTEERQRYIKEYMA----EVSNEKPSFWETMVKAIVQSSNQLEGQYEFMTH 125
               ::::.:|  :...::.|.:..|.|.    |:.|.  ||.|..:|..     .|..|::.|:.
Zfish    66 DRFSYQHFSV--SKSAQDMQDFFDELMRFSVFEMDNS--SFLEIQMKFF-----NLGSQHQDMSL 121

  Fly   126 PNVKEIYENPKI-------KFDLVFLGLMANTYQLGIAAKLKCPVIISW-----------VG-IP 171
            .....|.::|::       |||:|....|.....: :|.:|..|::.::           .| ||
Zfish   122 SYCDGILKSPELMDKLKKGKFDVVLSDPMYPCSDI-VAEELNVPLVYTFRFSVAHAAERMCGQIP 185

  Fly   172 LPFMDTIVGNVNDPSYVPTVNVALNAGQKTMDFGLRFVNFFKYAIMCVFETVLDYKMNQFYERAF 236
            .|           |||||.   |::.....|.|..|..|...|........::..:.:.:|...|
Zfish   186 AP-----------PSYVPG---AMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWRRFDNYYTEYF 236

  Fly   237 ANELEFPNYHEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKA- 300
            ...   .:|.||..:..:.....:...|.| ||.||....|||:.. ..|.||||::.:|:..:
Zfish   237 GRS---TSYCEMMGKADIWLIRTYWDFEFP-RPFVPNFKYIGGLHC-TPAKPLPKDMEEFVQSSG 296

  Fly   301 DEGAIFFSLGTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWEDLKNKP---GNASNIFFGNWLPQ 362
            |:|.:.|:||:.:  :....:..:.:...|:::||:|:|::..  .||   |..:.|:  .|:||
Zfish   297 DDGIVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYGG--EKPDTLGENTRIY--KWIPQ 355

  Fly   363 DDILAHPNTKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLD-ILTMTEH 426
            :|:|.||.|:.||||.|..||.||.|||||||.:|:||||..|...||.......:| |.:|...
Zfish   356 NDLLGHPKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQ 420

  Fly   427 ELEQTIREVLGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVAR 491
            ||...:..|:.:|:|:|...:.|.::.|||:......::|.|:|:|::||.||:....:..:...
Zfish   421 ELVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQY 485

  Fly   492 NNLDVYGVVLLVSLLLIVTIKFLFRKILNVAIGYGSQRKA 531
            :.|||:..:..| |.|::.|.|...|...:...:.|:||:
Zfish   486 HCLDVFAFLTTV-LTLVLYICFKMAKFFIMRCCFRSKRKS 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	147/502 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	132/456 (29%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	155/540 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910